OBJECTIVE To analyze the clinical outcomes, knee function, and activity level of patients after treatment of full-thickness cartilage defects involving the patellofemoral compartment of the knee with cryopreserved osteochondral allograft. DESIGN Nineteen patients with cartilage defects involving the patellofemoral compartment were treated. The average age was 31 years (range 15-45 years), including 12 females and 7 males. Patients were prospectively followed using validated clinical outcome measures including Veterans RAND 12-item Health Survey (VR-12), International Knee Documentation Committee (IKDC), Knee Injury and Osteoarthritis Outcome Score (KOOS), and the Tegner activity scale. Graft incorporation was evaluated by magnetic resonance imaging (MRI) or second-look arthroscopy. RESULTS The cartilage defects included the patella (n = 16) and the femoral trochlea (n = 3). Mean VR-12 scores increased from 31.6 to 46.3 (P < 0.01), mean IKDC increased from 40.0 to 69.7 (P < 0.01), mean KOOS increased from 53.9 to 80.2 (P < 0.01), and mean Tegner scores increased from 3.0 to 4.9 (P < 0.01), at average follow-up of 41.9 months (range 24-62 months). Of the 3 patients who underwent second-look arthroscopy, all demonstrated a well-incorporated graft. Mean MOCART score for the 6 patients with follow-up MRI was 62.5 (range 25-85). The reoperation rate was 21.1% and 2 patients (12.5%) experienced progressive patellofemoral osteoarthritis requiring conversion to patellofemoral arthroplasty. CONCLUSION Patients with unipolar cartilage defects involving the patellofemoral compartment of the knee can have positive outcomes at minimum 2-year follow-up after surgical treatment with a cryopreserved osteochondral allograft when concomitant pathology is also addressed, but the reoperation rate is high and bipolar cartilage lesions may increase the failure rate.

中文翻译：

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冷冻保存骨软骨同种异体移植物治疗髌股软骨缺损至少 2 年随访的预期结果。

目的分析冷冻保存的同种异体骨软骨移植治疗膝关节髌股间室全层软骨缺损后的临床疗效、膝关节功能及活动水平。设计 治疗了 19 名涉及髌股间室的软骨缺损患者。平均年龄31岁（15-45岁），其中女性12人，男性7人。使用经过验证的临床结果测量对患者进行前瞻性随访，包括退伍军人兰德 12 项健康调查 (VR-12)、国际膝关节文献委员会 (IKDC)、膝关节损伤和骨关节炎结果评分 (KOOS) 以及 Tegner 活动量表。通过磁共振成像 (MRI) 或二次关节镜检查评估移植物的结合。结果 软骨缺损包括髌骨（n = 16）和股骨滑车（n = 3）。平均 VR-12 分数从 31.6 增加到 46.3 (P < 0.01)，平均 IKDC 从 40.0 增加到 69.7 (P < 0.01)，平均 KOOS 从 53.9 增加到 80.2 (P < 0.01)，平均 Tegner 分数从 3.0 增加到4.9 (P < 0.01)，平均随访 41.9 个月（范围 24-62 个月）。在接受二次关节镜检查的 3 名患者中，所有患者均表现出良好结合的移植物。6 名 MRI 随访患者的平均 MOCART 评分为 62.5（范围 25-85）。再次手术率为 21.1%，2 名患者 (12.5%) 出现进行性髌股骨关节炎，需要转换为髌股关节置换术。