Controlled release (CR) nanoformulations of Mancozeb (Manganese-zinc double salt of N, N-bisdithiocarbamic acid), a protective fungicide, have been developed using poly (ethylene glycols) (PEGs) based functionalized amphiphilic copolymers and evaluated for the management of early blight in tomato. During the field experiment, it was observed that number of infected leaflets/plants were less in developed formulation treated plants as compared to commercial products. Number of infected leaflets per plant was 2.40-4.60 and the number of fruits per plant were 6.40-9.00 at 50 mg L-1, whereas at 100 mg L-1, the corresponding numbers were 2.10-4.10 and 6.30-9.10 respectively. These formulations can be used to optimize the release of Mancozeb to achieve disease control for the desired period depending upon the matrix of the polymer used. Importantly, sufficient amount of active ingredient remains available for a reasonable period of time after application leading to reduced number of applications of pesticide.

中文翻译：

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基于两亲性聚合物的Mancozeb纳米制剂，可用于处理番茄中的早疫病。

使用基于聚乙二醇（PEG）的功能性两亲共聚物开发了Mancozeb（N，N-双二硫代氨基甲酸的锰锌复盐）的控释（CR）纳米制剂，并已对其进行了评估，以用于早期管理在番茄中枯萎。在田间试验中，观察到与商业产品相比，在发达的配方处理植物中感染的小叶/植物的数量更少。在50 mg L-1下，每株植物感染的小叶数为2.40-4.60，每株植物上的果实数为6.40-9.00，而在100 mg L-1下，相应的数分别为2.10-4.10和6.30-9.10。这些制剂可用于优化Mancozeb的释放，以根据所用聚合物的基质在所需时期内控制疾病。重要的，