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Approaches to optimize therapeutic bacteriophage and bacteriophage-derived products to combat bacterial infections.
Virus Genes ( IF 1.6 ) Pub Date : 2020-02-08 , DOI: 10.1007/s11262-020-01735-7
Monika Reuter 1 , Detlev H Kruger 1
Affiliation  

The emerging occurrence of antibiotic-resistant bacterial pathogens leads to a recollection of bacteriophage as antimicrobial therapeutics. This article presents a short overview of the clinical phage application including their use in military medicine and discusses the genotypic and phenotypic properties of a potential "ideal" therapeutic phage. We describe current efforts to engineer phage for their improved usability in pathogen treatment. In addition, phage can be applied for pathogen detection, selective drug delivery, vaccine development, or food and surface decontamination. Instead of viable phage, (engineered) phage-derived enzymes, such as polysaccharide depolymerases or peptidoglycan-degrading enzymes, are considered as promising therapeutic candidates. Finally, we briefly summarize the use of phage for the detection and treatment of "Category A priority pathogens".

中文翻译:

优化治疗性噬菌体和噬菌体衍生产品以对抗细菌感染的方法。

抗生素抗性细菌病原体的出现导致了噬菌体作为抗菌治疗剂的回收。本文简要介绍了临床噬菌体的应用,包括其在军事医学中的用途,并讨论了潜在的“理想”治疗噬菌体的基因型和表型特性。我们描述了当前努力工程化噬菌体以提高其在病原体治疗中的可用性。另外,噬菌体可用于病原体检测,选择性药物递送,疫苗开发或食品和表面净化。(工程)噬菌体衍生的酶,例如多糖解聚酶或肽聚糖降解酶,被代替了活的噬菌体,被认为是有前途的治疗候选物。最后,
更新日期:2020-02-08
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