Hypnotic-focused analgesia (HFA) was produced in 20 highly hypnotizable subjects receiving nociceptive stimulations while undergoing functional magnetic resonance imaging (fMRI). The fMRI pattern in brain cortex activation while receiving a painful stimulus was recorded both during nonhypnosis and during HFA. The scanning protocol included the acquisition of a T1-weighted structural scan, 4 functional scans, a T2-weighted axial scan, and a fluid attenuated inversion recovery (FLAIR) scan. Total imaging time, including localization and structural image acquisitions, was approximately 60 minutes. Without HFA, the subjects reported subjective presence of pain, and the cortex primary sensory areas S1, S2, and S3 were activated. During HFA, the subjects reported complete absence of subjective pain and S1, S2, and S3 were deactivated. The findings suggest that HFA may prevent painful stimuli from reaching the sensory brain cortex, possibly through a gate-control mechanism.

中文翻译：

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功能性磁共振（fMRI）解释的催眠镇痛机理。

在进行功能性磁共振成像（fMRI）时，在接受伤害性刺激的20位高度催眠的受试者中产生了以催眠为重点的镇痛（HFA）。在非催眠过程中和HFA期间均记录了在接受疼痛刺激时大脑皮质激活的功能磁共振成像模式。扫描协议包括获取T1加权结构扫描，4个功能扫描，T2加权轴向扫描和流体衰减反转恢复（FLAIR）扫描。包括定位和结构图像获取在内的总成像时间约为60分钟。没有HFA，受试者报告主观疼痛的存在，并且皮层主要感觉区域S1，S2和S3被激活。在HFA期间，受试者报告完全没有主观疼痛，并且S1，S2和S3被停用。