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Model of Morphogenesis.
Journal of Computational Biology ( IF 1.7 ) Pub Date : 2020-09-04 , DOI: 10.1089/cmb.2019.0414
Yue Wang 1 , Andrey Minarsky 2 , Robert Penner 1 , Christophe Soulé 1, 3 , Nadya Morozova 1, 4, 5
Affiliation  

We build a theoretical model of morphogenesis. This model describes cell fate in the developing organism using the notion of epigenetic code of each cell. Namely, given the epigenetic spectra of a cell and its neighboring cells, we can determine the corresponding cell event it will perform. This means that the properties of a group of cells (comprising an embryo or its part) at any time point are also known, and thus, the evolution of an embryo can be described. By this strategy, it is possible to establish the tissue, organ, or embryo shapes at any time, starting from a zygote. As an essential part of the model, the formalization of the notion of cell potency is introduced, and the related properties are discussed.

中文翻译:

形态发生模型。

我们建立了形态发生的理论模型。该模型使用每个细胞的表观遗传密码的概念来描述发育中生物体的细胞命运。也就是说,给定一个细胞及其相邻细胞的表观遗传谱,我们可以确定它将执行的相应细胞事件。这意味着一组细胞(包括胚胎或其部分)在任何时间点的特性也是已知的,因此可以描述胚胎的进化。通过这种策略,可以随时从受精卵开始建立组织、器官或胚胎形状。作为模型的重要组成部分,介绍了细胞潜能概念的形式化,并讨论了相关特性。
更新日期:2020-09-14
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