Introduction Glioma is an aggressive common cancer with high mortality worldwide. Up to date, the effective medical therapeutical strategy is limited. Numerous previous studies have indicated that glioma-expressed antigen 2 (GLEA2) might be an attractive prognostic glioma biomarker. Methods In this experiment, dendritic cells (DCs) transduced with GLEA2 recombinant adenovirus were utilized to generate cytotoxic lymphocytes (CTLs) in vitro. Additionally, trimera mice were immunized with the transduced DCs to generate CTLs in vivo. Results The data demonstrated that GLEA2 transduced DCs could effectively generate specific CTL response against glioma without lysing autologous lymphocytes. Moreover, GLEA2 transduced DCs significantly attenuated the tumor growth and prolonged the life span of tumor bearing mice. Conclusions These findings suggested that DCs transduced with GLEA2 recombinant adenovirus could generate effective CTL mediated anti-tumor response, and might represent insight in glioma therapy.

中文翻译：

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用神经胶质瘤表达的抗原 2 重组腺病毒转导的树突状细胞在小鼠中诱导特异性细胞毒性淋巴细胞反应和抗肿瘤作用。

简介 胶质瘤是一种侵袭性的常见癌症，在全球范围内死亡率很高。迄今为止，有效的医学治疗策略是有限的。许多先前的研究表明，胶质瘤表达的抗原 2 (GLEA2) 可能是一种有吸引力的预后胶质瘤生物标志物。方法在本实验中，利用转导GLEA2重组腺病毒的树突状细胞（DCs）在体外产生细胞毒性淋巴细胞（CTLs）。此外，用转导的 DC 对三聚体小鼠进行免疫以在体内产生 CTL。结果数据表明，GLEA2转导的DC可以有效地产生针对神经胶质瘤的特异性CTL反应，而不会溶解自体淋巴细胞。此外，GLEA2 转导的 DC 显着减弱了肿瘤生长并延长了荷瘤小鼠的寿命。