Dopamine provides crucial neuromodulatory functions in several insect and rodent learning and memory paradigms. However, an early study suggested that dopamine may be dispensable for aversive place memory in Drosophila. Here we tested the involvement of particular dopaminergic neurons in place learning and memory. We used the thermogenetic tool Gr28bD to activate protocerebral anterior medial (PAM) cluster and non-PAM dopaminergic neurons in an operant way in heat-box place learning. We show that activation of PAM neurons influences performance during place learning, but not during memory testing. These findings provide a gateway to explore how dopamine influences place learning.

中文翻译：

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多巴胺能神经元可以影响果蝇中的热盒位置学习。

多巴胺在几种昆虫和啮齿动物的学习和记忆范例中提供关键的神经调节功能。然而，一项早期研究表明，多巴胺对于果蝇的厌恶位置记忆可能是可有可无的。在这里，我们测试了特定多巴胺能神经元在学习和记忆中的参与。我们使用热遗传工具 Gr28bD 在热箱位置学习中以操作性方式激活原大脑前内侧 (PAM) 簇和非 PAM 多巴胺能神经元。我们表明 PAM 神经元的激活会影响地点学习期间的表现，但不会影响记忆测试期间的表现。这些发现为探索多巴胺如何影响地方学习提供了途径。