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The Suppressive Attitude of Inflammatory Monocytes in Antiviral Antibody Responses.
Viral Immunology ( IF 2.2 ) Pub Date : 2020-05-13 , DOI: 10.1089/vim.2019.0132
Eleonora Sala 1 , Mirela Kuka 1
Affiliation  

Inflammatory monocytes play important functions in antiviral immune responses, including release of inflammatory cytokines and antigen presentation to T lymphocytes. Depending on the pathological context, these functions might translate into beneficial or detrimental effects in the resolution of the disease. Recent literature has highlighted a role for inflammatory monocytes also in direct suppression of B cell responses. In this review, we will briefly discuss research showing the relationship between inflammatory monocytes and B lymphocytes, its functional consequences on antiviral antibody responses, and possible implications in the design of future vaccination strategies.

中文翻译:

抗病毒抗体反应中炎性单核细胞的抑制态度。

炎性单核细胞在抗病毒免疫反应中起重要作用,包括释放炎性细胞因子和向T淋巴细胞呈递抗原。根据病理情况,这些功能可能会转化为解决疾病的有益或有害作用。最近的文献强调了炎性单核细胞在直接抑制B细胞反应中的作用。在这篇综述中,我们将简要讨论研究,这些研究表明炎症性单核细胞和B淋巴细胞之间的关系,其对抗病毒抗体反应的功能后果以及在未来疫苗接种策略设计中的潜在意义。
更新日期:2020-05-13
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