Abstract

The hydrotropy though existing as precisely used scientific approach assisting solubilization for all. It took 66 long years to use the concept in drug analysis since its inception in 1916 and first use for facilitation of drug solubility toward better pharmaceutical analysis in 1982. Considering the unending importance in pharmaceutical sciences and thereby in analysis, it’s a necessity to comprehensively outlook the origin, evolution, cumulative trend and precise applications in pharmaceutical analysis. Achieved hereby with chronological and comparative assessment of the studies published pertaining to solubility enhancement of poorly soluble drugs with use of hydrotropic agents alone or in combination for assisting pharmaceutical analysis. The thorough literature searches resulted into 77 references over a span of about 38 years. This comprehensive review critically evaluates existing literature; to our surprise we found Ibuprofen sodium, Lignocaine, Niacinamide and Metformin HCl as atypical hydrotropic agents. We also compared herein mono and mixed approaches which indicated prevalence of mono - hydrotropy over mixed. The possible mechanisms behind solubilization are presented for an additional insight. An essential effort has been made to state arbitrary classification to assist in future applications. The obvious purpose of this study was to collectively evaluate the crucial role of hydrotropic agents in pharmaceutical analyses for better drug delivery. This comprehensive review covers all details since inception to the updates till date which will definitely act as appropriate guideline for pharmaceutical analyst’s in need of hydrotropy to assist pharmaceutical analysis for therapies today and tomorrow.

摘要

水溶性虽然存在，但作为精确使用的科学方法帮助所有人溶解。该概念自 1916 年问世以来，历经 66 年的漫长岁月，并于 1982 年首次用于促进药物溶解度以实现更好的药物分析。药物分析中的起源、演变、累积趋势和精确应用。特此通过对已发表的研究的时间顺序和比较评估来实现，这些研究涉及单独使用或联合使用助水剂以辅助药物分析来增强难溶性药物的溶解度。在大约 38 年的时间里，彻底的文献搜索产生了 77 篇参考文献。这篇综合评论批判性地评估了现有文献；令我们惊讶的是，我们发现布洛芬钠、利多卡因、烟酰胺和盐酸二甲双胍是非典型的水溶助剂。我们还在本文中比较了单水溶方法和混合方法，这表明单水溶比混合更普遍。提出了增溶背后的可能机制，以获得额外的洞察力。已经做出了必要的努力来说明任意分类以协助未来的应用。这项研究的明显目的是共同评估助水剂在药物分析中的关键作用，以实现更好的药物输送。