Pruritus is a major symptom of atopic dermatitis (AD) and is transmitted by a subpopulation of non‐myelinated C‐type free nerve endings in the epidermis and upper dermis. Stimulation of these nerve terminals is affected by histamine, neurotrophins and physical factors. Eosinophils of patients with AD are a source of neurotrophins, including brain‐derived neurotrophic factor (BDNF), levels of which correlate with disease severity.

中文翻译：

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感觉神经元的神经元分支与特应性皮炎中的 BDNF 阳性嗜酸性粒细胞有关

瘙痒是特应性皮炎 (AD) 的主要症状，由表皮和真皮上部的无髓鞘 C 型游离神经末梢亚群传播。这些神经末梢的刺激受组胺、神经营养因子和物理因素的影响。AD 患者的嗜酸性粒细胞是神经营养因子的来源，包括脑源性神经营养因子 (BDNF)，其水平与疾病严重程度相关。