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The impact of the gut microbiota on prognosis after surgery for colorectal cancer - a systematic review and meta-analysis.
APMIS ( IF 2.8 ) Pub Date : 2020-02-01 , DOI: 10.1111/apm.13032
Emilie Palmgren Colov 1, 2 , Thea Helene Degett 2, 3 , Hans Raskov 2 , Ismail Gögenur 2, 4, 5
Affiliation  

The aim of this study was to conduct a systematic review of the association between gut microbiota and prognosis after colorectal cancer surgery. The review was conducted according to the PRISMA guidelines. A systematic literature search was conducted in PubMed, Embase, and Scopus. Studies examining the association between gut microbiota and survival after colorectal cancer surgery were identified. Secondary outcomes were association with cancer stage and immune infiltration of tumor. A total of 27 studies were included in the review. Fusobacterium nucleatum was the most frequently examined bacterium, and the meta-analysis showed that high level of F. nucleatum was significantly associated with decreased overall survival, hazard ratio of 1.63 (95% confidence interval 1.23-2.16) for unadjusted data, and hazard ratio of 1.47 (95% confidence interval 1.08-1.98) for adjusted data. Association between higher tumor stage and F. nucleatum was reported in ten studies, and two studies found an association with unfavorable tumor infiltration of immune cells. Three out of five studies examining Bacteroides fragilis found an association with decreased survival, advanced tumor stage, or unfavorable immune infiltration of tumor. High levels of F. nucleatum and possibly B. fragilis were associated with worse prognosis after surgery for colorectal cancer.

中文翻译:

肠道菌群对结直肠癌手术后预后的影响-系统评价和荟萃分析。

这项研究的目的是对大肠癌手术后肠道菌群与预后之间的关系进行系统的回顾。审查是根据PRISMA指南进行的。在PubMed,Embase和Scopus中进行了系统的文献检索。确定了检查肠道菌群与结直肠癌手术后存活之间关系的研究。次要结果与癌症分期和肿瘤的免疫浸润有关。该评价共纳入27项研究。核梭状芽胞杆菌是检查频率最高的细菌,荟萃分析显示,高浓度的核梭菌与总体存活率下降,未调整数据的危险比为1.63(95%置信区间1.23-2.16)和危险比显着相关。共1。47(95%置信区间1.08-1.98),用于调整后的数据。在十项研究中报告了更高的肿瘤分期与核仁之间的联系,两项研究发现与免疫细胞的肿瘤浸润有关。在研究脆弱型拟杆菌的五分之三的研究中,发现其与存活率降低,肿瘤分期进展或肿瘤的免疫浸润不良有关。高浓度的核仁和可能的脆性芽孢杆菌与大肠癌手术后的预后较差有关。或肿瘤的免疫浸润不良。高浓度的核仁和可能的脆性芽孢杆菌与大肠癌手术后的预后较差有关。或肿瘤的免疫浸润不良。高浓度的核仁和可能的脆性芽孢杆菌与大肠癌手术后的预后较差有关。
更新日期:2020-04-30
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