Animal based research needs to strictly adhere to the 3R principle (replace, refine, reduce), not only for the ethical justification of the use of animals in science, but also to ensure the highest quality of data due to standardization. With the implementation of the EU Directive 2010/63 within national law it is mandatory to perform a ‘severity classification of procedures on the basis of estimated levels of pain, suffering, distress and lasting harm that is inflicted on the animals’.

中文翻译：

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基于动物的研究中的严重性评估。

基于动物的研究需要严格遵守3R原则（替换，改进，减少），这不仅是出于科学上对动物使用的道德考虑，而且还需要确保标准化带来的最高数据质量。在国家法律内实施欧盟指令2010/63的情况下，必须根据对动物造成的疼痛，痛苦，窘迫和持久伤害的估计水平对程序进行严重程度分类。