REASONS FOR THE STUDY The Neuropsychiatric Inventory (NPI) has been used for studies of neuropsychiatric symptoms in neurodegenerative disorders for the past 25 years. This article reviews the history of the development and application of the NPI. MAIN FINDINGS The NPI consists of 10 (or 12) items that are assayed with questions, subquestions, and ratings of frequency and severity. The NPI has been shown to be valid and reliable. The NPI has been translated into approximately 40 languages; it has 4 of versions designed for different clinical applications. The NPI studies show contrasting profiles of behavioral symptoms in different neurologic disorders. The NPI has been used in approximately 350 clinical trials. In economic studies, the NPI captures the cost of behavioral symptoms in dementias. PRINCIPLE CONCLUSIONS The NPI is a useful instrument for capturing behavioral changes in Alzheimer disease and other neurodegenerative disorders.

中文翻译：

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神经精神病学清单：发展和应用。

研究理由 在过去的 25 年中，神经精神量表 (NPI) 一直用于研究神经退行性疾病的神经精神症状。本文回顾了NPI的发展和应用历史。主要发现 NPI 由 10（或 12）个项目组成，这些项目通过问题、子问题以及频率和严重程度的评级进行分析。NPI 已被证明是有效和可靠的。NPI 已被翻译成大约 40 种语言；它有 4 个版本，专为不同的临床应用而设计。NPI 研究显示了不同神经系统疾病中行为症状的不同特征。NPI 已用于大约 350 项临床试验。在经济研究中，NPI 记录了痴呆症行为症状的成本。