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Impact of food challenge on local oesophageal immunophenotype in eosinophilic oesophagitis
Clinical & Experimental Allergy ( IF 6.1 ) Pub Date : 2020-04-01 , DOI: 10.1111/cea.13578
Hamish Philpott 1 , Shawn Zhenhui Lee 1 , Ashley Arrington 2 , Sarah J McGee 2 , Evan S Dellon 2
Affiliation  

Eosinophilic oesophagitis (EoE) is caused by the ingestion of food antigens. Dietary avoidance can result in clinical and histological remission, while food reintroduction can cause recurrence. It is uncertain if food antigen processing and immune activation occurs locally, in the oesophagus. Therefore, we performed a comparative study of the density of cell surface proteins (known to be involved with antigen presentation) on oesophageal tissue prior to, and following food antigen induced disease recurrence. A secondary aim was to consider novel biomarkers.

中文翻译:

食物刺激对嗜酸性粒细胞性食管炎局部食管免疫表型的影响

嗜酸性粒细胞性食管炎 (EoE) 是由摄入食物抗原引起的。饮食避免可导致临床和组织学缓解,而重新引入食物可导致复发。不确定食物抗原加工和免疫激活是否在食管局部发生。因此,我们对食物抗原诱导的疾病复发之前和之后食管组织上细胞表面蛋白(已知与抗原呈递有关)的密度进行了比较研究。次要目的是考虑新的生物标志物。
更新日期:2020-04-01
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