In recent years, there has been a renewed interest in utilizing antibody fragment crystallizable (Fc) functions to prevent and control viral infections. The protective and therapeutic potential of Fc-mediated antibody functions have been assessed for some clinically important human viruses, including HIV, hemorrhagic fever viruses and influenza virus. There is mounting evidence that influenza-specific antibodies with Fc-mediated functions, such as antibody-dependent cellular cytotoxicity and antibody-dependent phagocytosis, can aid in the clearance of influenza virus infection. Recent influenza challenge studies and intravenous immunoglobulin G therapy studies in humans suggest a protective role for Fc effector functions in vivo. Broadly reactive influenza antibodies with Fc-mediated functions are prevalent in the human population and could inform the development of a universally protective influenza vaccine or therapy. In this review, we explore the utility of antibodies with Fc-mediated effector functions against viral infections with a focus on influenza virus.

中文翻译：

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Fc介导的抗体的保护潜力可抵抗流感病毒和其他病毒病原体。

近年来，人们开始关注利用可结晶的抗体片段（Fc）功能来预防和控制病毒感染。已对某些临床上重要的人类病毒，包括HIV，出血热病毒和流感病毒，评估了Fc介导的抗体功能的保护性和治疗潜力。越来越多的证据表明，具有Fc介导功能的流感特异性抗体，例如抗体依赖性细胞毒性和抗体依赖性吞噬作用，可以帮助清除流感病毒感染。最近的人类流感挑战研究和静脉内免疫球蛋白G治疗研究表明，体内Fc效应子功能具有保护作用。具有Fc介导功能的广泛反应性流感抗体在人群中十分普遍，可为普遍保护性流感疫苗或疗法的发展提供信息。在这篇综述中，我们探索了具有Fc介导的效应子功能的抗体针对病毒感染的效用，重点是流感病毒。