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Th17 and Cognitive Impairment: Possible Mechanisms of Action.
Frontiers in Neuroanatomy ( IF 2.9 ) Pub Date : 2019-11-19 , DOI: 10.3389/fnana.2019.00095
Virginia Cipollini 1 , Josef Anrather 2 , Francesco Orzi 1 , Costantino Iadecola 2
Affiliation  

T helper 17 (Th17) cells represent a distinct population of immune cells, important in the defense of the organism against extracellular infectious agents. Because of their cytokine profile and ability to recruit other immune cell types, they are highly pro-inflammatory and are involved in the induction of several autoimmune disorders. Recent studies show that Th17 cells and their signature cytokine IL-17 have also a role in a wide variety of neurological diseases. This review article will briefly summarize the evidence linking Th17 cells to brain diseases associated with cognitive impairment, including multiple sclerosis (MS), ischemic brain injury and Alzheimer's disease (AD). We will also investigate the mechanisms by which these cells enter the brain and induce brain damage, including direct effects of IL-17 on brain cells and indirect effects mediated through disruption of the blood-brain barrier (BBB), neurovascular dysfunction and gut-brain axis. Finally, therapeutic prospects targeting Th17 cells and IL-17 will be discussed.

中文翻译:

Th17和认知障碍:可能的作用机制。

T辅助细胞17(Th17)细胞代表着独特的免疫细胞群,在保护生物体抵抗细胞外感染因子方面很重要。由于它们的细胞因子特征和募集其他免疫细胞类型的能力,它们具有高度促炎性,并参与多种自身免疫性疾病的诱发。最近的研究表明Th17细胞及其标志性细胞因子IL-17在多种神经系统疾病中也起作用。本文将简要概述将Th17细胞与与认知障碍相关的脑部疾病相关的证据,包括多发性硬化症(MS),缺血性脑损伤和阿尔茨海默氏病(AD)。我们还将研究这些细胞进入大脑并诱导脑损伤的机制,包括IL-17对脑细胞的直接作用以及通过破坏血脑屏障(BBB),神经血管功能障碍和肠脑轴介导的间接作用。最后,将讨论靶向Th17细胞和IL-17的治疗前景。
更新日期:2019-11-19
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