Chemodynamic therapy (CDT) takes the advantages of Fenton-type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli-activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli-activatable nanomedicine for clinical translation and future development of CDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.

中文翻译：

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可刺激激活的纳米药物，用于癌症的化学动力学治疗。

化学动力疗法（CDT）利用内源性化学能触发的Fenton型反应的优势，产生高度细胞毒性的羟基自由基。作为一种新型的癌症治疗手段，CDT通过对肿瘤的酸性和高浓度过氧化氢微环境作出反应，显示出最小的侵袭性和较高的肿瘤特异性。用于时空可控制的活性氧生成的CDT方法具有较好的治疗性能和令人满意的生物安全性。在这篇综述文章中，我们总结了CDT的可刺激激活纳米药物的最新进展。我们还概述了增强CDT性能的策略，包括通过合理设计纳米材料，调节反应条件，输入外部能量场，并调节肿瘤的微环境。此外，我们讨论了可激活的纳米药物在CDT的临床翻译和未来发展中的潜力和挑战。本文归类于：治疗方法和药物发现>肿瘤疾病的纳米药物生物学的纳米技术>生物学诊断工具中的纳米系统>体内纳米诊断和成像。