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Efficacy of frameless stereotactic radiotherapy for the treatment of presumptive canine intracranial gliomas: A retrospective analysis (2014-2017).
Veterinary and Comparative Oncology ( IF 2.1 ) Pub Date : 2020-02-03 , DOI: 10.1111/vco.12573
Steven J Moirano 1 , Curtis W Dewey 2, 3, 4 , Siobhan Haney 5 , Jun Yang 6
Affiliation  

The use of conventional multi‐fractionated radiotherapy for the treatment of glial tumours is well documented in the literature. Recently, stereotactic radiotherapy (SRT) has become more widely available allowing for hypo‐fractionated protocols; however, its usefulness in the treatment of canine intracranial gliomas is largely undetermined. We conducted a retrospective analysis, including 21 dogs diagnosed with presumptive intracranial gliomas treated with one or more courses of three fractions of 8 to 10 Gy CyberKnife SRT. The objective of this study was to evaluate the efficacy, safety and prognostic factors associated with the use of SRT for the treatment of canine intracranial gliomas. Overall MST for all dogs was 636 days (d). Dogs treated with one course of the described SRT protocol had a MST of 258 days while those treated with >1 course had a MST of 865 days (P = .0077 log rank, 0.0139 Wilcoxon). Dogs treated with one course of SRT who received adjuvant chemotherapy had a MST of >658 days and lived significantly longer than those who did not receive chemotherapy (MST, 230 days) (P = .0414 log rank, 0.0453 Wilcoxon). The most common adverse event included presumptive transient demyelination in 3/21 dogs, which was treated successfully with corticosteroids in all patients. This study provides evidence that SRT is effective in prolonging survival in dogs with intracranial gliomas, and may provide similar results to conventional fractionated protocols, while decreasing the number of hospital visits and anaesthetic episodes. Additionally, it appears that patients can be safely treated with multiple rounds of SRT resulting in improved survival times.

中文翻译:

无框立体定向放射治疗推定犬颅内胶质瘤的疗效:回顾性分析(2014-2017)。

使用传统的多分割放疗治疗胶质瘤在文献中有充分的记载。最近,立体定向放射治疗 (SRT) 变得更加广泛,允许大分割方案;然而,它在治疗犬颅内胶质瘤中的有效性在很大程度上尚未确定。我们进行了一项回顾性分析,包括 21 只被诊断患有推定颅内神经胶质瘤的狗,这些狗接受了一个或多个疗程的 8 至 10 Gy Cyber​​Knife SRT 三个部分的治疗。本研究的目的是评估与使用 SRT 治疗犬颅内胶质瘤相关的疗效、安全性和预后因素。所有狗的总体 MST 为 636 天 (d)。用一个疗程的所述 SRT 方案治疗的狗的 MST 为 258 天,而那些用 >P = .0077 对数等级,0.0139 Wilcoxon)。接受辅助化疗的狗接受了一个疗程的 SRT,其 MST > 658 天,并且比未接受化疗的狗(MST,230 天)寿命显着更长(P = .0414 对数秩,0.0453 Wilcoxon)。最常见的不良事件包括 3/21 犬推定的短暂性脱髓鞘,所有患者均使用皮质类固醇成功治疗。这项研究提供的证据表明 SRT 可有效延长患有颅内胶质瘤的狗的生存期,并且可能提供与传统分割方案相似的结果,同时减少住院次数和麻醉发作次数。此外,似乎可以通过多轮 SRT 安全地治疗患者,从而延长生存时间。
更新日期:2020-02-03
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