The majority of all cancers metastasize initially through the lymphatic system. Despite this, the mechanisms of lymphogenous metastasis remain poorly understood and understudied compared to hematogenous metastasis. Over the past few decades, microfluidic devices have been used to model pathophysiological processes and drug interactions in numerous contexts. These devices carry many advantages over traditional 2D in vitro systems, allowing for better replication of in vivo microenvironments. This review highlights prominent fluidic devices used to model the stages of cancer metastasis via the lymphatic system, specifically within lymphangiogenesis, vessel permeability, tumor cell chemotaxis, transendothelial migration, lymphatic circulation, and micrometastases within the lymph nodes. In addition, we present perspectives for the future roles that microfluidics might play within these settings and beyond.

中文翻译：

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设计流体系统以了解淋巴癌转移。

所有癌症中的大多数最初都是通过淋巴系统转移的。尽管如此，与血源性转移相比，淋巴源性转移的机制仍知之甚少。在过去的几十年中，在许多情况下，微流体装置已被用于建模病理生理过程和药物相互作用。与传统的2D体外系统相比，这些设备具有许多优势，从而可以更好地复制体内微环境。这篇综述重点介绍了用于模拟通过淋巴系统转移的阶段的重要流体装置，特别是在淋巴管生成，血管通透性，肿瘤细胞趋化性，跨内皮迁移，淋巴循环和淋巴结内微转移方面。此外，