Bacteria are widely used for commercially producing biomolecules. However, attempts to rationally design production strains and optimize cultivation conditions are frequently counteracted by the emergence of mutants with reduced production characteristics that decrease overall process yield. The reason why these mutants arise is likely because of a mismatch between the ecological conditions under which bacteria evolved in nature and the situation they experience in an industrial setting. Thus, there is a great potential for improving biotechnological production processes by implementing eco-evolutionary knowledge. However, this is often limited by a lack of effective communication between process engineers and microbial ecologists/evolutionary biologists. Here, we highlight recent findings in the field of microbial ecology and evolution and suggest implementation of this knowledge can significantly enhance microbial bioproduction.

中文翻译：

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利用生态和进化原理指导微生物生产联盟的设计。

细菌被广泛用于商业生产生物分子。然而，合理地设计生产菌株和优化培养条件的尝试经常被生产特性降低的突变体的出现所抵消，这些突变体降低了总工艺产量。这些突变体出现的原因很可能是由于细菌在自然环境中进化所处的生态条件与其在工业环境中所经历的情况之间的不匹配所致。因此，通过实施生态进化知识，具有改善生物技术生产过程的巨大潜力。但是，这通常受到制程工程师与微生物生态学家/进化生物学家之间缺乏有效沟通的限制。这里，