ABSTRACT Bone is a complex organ possessing both physicomechanical and bioelectrochemical properties. In the view of Wolff’s Law, bone can respond to mechanical loading and is subsequently reinforced in the areas of stress. Piezoelectricity is one of several mechanical responses of the bone matrix that allows osteocytes, osteoblasts, osteoclasts, and osteoprogenitors to react to changes in their environment. The present review details how osteocytes convert external mechanical stimuli into internal bioelectrical signals and the induction of intercellular cytokines from the standpoint of piezoelectricity. In addition, this review introduces piezoelectric and triboelectric materials used as self-powered electrical generators to promote osteogenic proliferation and differentiation due to their electromechanical properties, which could promote the development of promising applications in tissue engineering and bone regeneration. GRAPHICAL ABSTRACT

中文翻译：

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纳米发电机和压电在成骨中的应用

摘要 骨骼是一种复杂的器官，同时具有物理力学和生物电化学特性。根据沃尔夫定律，骨骼可以对机械载荷做出反应，并随后在应力区域得到加强。压电是骨基质的几种机械反应之一，它允许骨细胞、成骨细胞、破骨细胞和骨祖细胞对其环境的变化做出反应。本综述从压电的角度详细介绍了骨细胞如何将外部机械刺激转化为内部生物电信号以及细胞间细胞因子的诱导。此外，本综述介绍了用作自供电发电机的压电和摩擦电材料，由于其机电特性，可促进成骨增殖和分化，这可以促进在组织工程和骨再生方面有前景的应用的发展。图形概要