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Merkel cell polyomavirus detected in head and neck carcinomas from Chile
Infectious Agents and Cancer ( IF 3.7 ) Pub Date : 2020-01-28 , DOI: 10.1186/s13027-020-0276-z
Juan P Muñoz 1 , Rancés Blanco 2 , Julio C Osorio 2 , Carolina Oliva 2 , María José Diaz 2 , Diego Carrillo-Beltrán 2 , Rebeca Aguayo 3 , Andrés Castillo 4 , Julio C Tapia 5 , Gloria M Calaf 1, 6 , Aldo Gaggero 2 , Francisco Aguayo 1, 2, 7
Affiliation  

Background The role of human polyomaviruses (HPyVs) in epithelial tumors such as head and neck carcinomas (HNSCCs) including oral and oropharyngeal carcinomas has not been established. In this study, we evaluated for the first time the presence of Merkel cell polyomavirus (MCPyV), BK human polyomavirus (BKPyV), and JC human polyomavirus (JCPyV) in HNSCCs from Chilean subjects. Methods One hundred and twenty HNSCCs were analyzed for the presence of MCPyV, BKPyV and JCPyV using real-time polymerase chain reaction procedures. In addition, 54 oral brushes from age- and sex-paired subjects were analyzed. Results Of the total of 120 HNSCCs, 15 were positive for MCPyV (12.5%). Only one case was positive for BKPyV (0.8%) and none for JCPyV (0%). In subjects without cancer, only one case (1.8%) resulted positive for MCPyV and none for JCPyV and BKPyV. MCPyV was associated with HNSCCs ( p = 0.0239; OR = 7.571; 95% CI: 1.192–81.46). No association was found between age ( p = 0.1996), gender ( p = 0.7111) or differentiation status ( p > 0.9999) and MCPyV presence in HNSCCs. Conclusions MCPyVs were detected in HNSCCs from Chilean patients and were not detected in oral brushes from patients without cancer. More studies are warranted for defining an etiological role and clinical/molecular consequences of these viruses in HNSCCs.

中文翻译:

在智利的头颈癌中检测到默克尔细胞多瘤病毒

背景 人类多瘤病毒 (HPyVs) 在上皮肿瘤中的作用,如头颈癌 (HNSCC),包括口腔和口咽癌,尚未确定。在这项研究中,我们首次评估了智利受试者 HNSCC 中默克尔细胞多瘤病毒 (MCPyV)、BK 人多瘤病毒 (BKPyV) 和 JC 人多瘤病毒 (JCPyV) 的存在。方法 使用实时聚合酶链反应程序分析了 120 个 HNSCC 中 MCPyV、BKPyV 和 JCPyV 的存在。此外,还分析了来自年龄和性别配对受试者的 54 支口腔刷。结果 120 例 HNSCC 中,15 例 MCPyV 阳性(12.5%)。只有 1 例 BKPyV 阳性(0.8%),JCPyV 无阳性(0%)。在没有癌症的受试者中,只有 1 例 (1.8%) MCPyV 呈阳性,而 JCPyV 和 BKPyV 则没有。MCPyV 与 HNSCC 相关(p = 0.0239;OR = 7.571;95% CI:1.192–81.46)。在 HNSCCs 中年龄 (p = 0.1996)、性别 (p = 0.7111) 或分化状态 (p > 0.9999) 与 MCPyV 存在之间没有发现关联。结论 在智利患者的 HNSCC 中检测到 MCPyV,而在非癌症患者的口腔刷中未检测到 MCPyV。需要更多的研究来确定这些病毒在 HNSCC 中的病因学作用和临床/分子后果。
更新日期:2020-01-28
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