BACKGROUND Thoracolumbar myelopathies associated with spinal cord and vertebral column lesions, with a similar clinical phenotype, but different underlying etiologies, occur in pugs. OBJECTIVES To further characterize the clinical and neuropathological characteristics of pugs with longstanding thoracolumbar myelopathy. ANIMALS Thirty client-owned pure-bred pugs with a history of more than a month of ataxia and paresis of the pelvic limbs, suggesting a myelopathy localized to the thoracolumbar spinal cord, were included in the study. METHODS Prospective clinicopathological study. Included pugs underwent a complete neurological examination and gross and histopathologic postmortem studies with focus on the spinal cord. Computed tomography (n = 18), magnetic resonance imaging (n = 17), and cerebrospinal fluid analysis (n = 27) were performed before or immediately after death. RESULTS Twenty male and 10 female pugs had a median age at clinical onset of 84 months (interquartile range, 66-96). Affected pugs presented with a progressive clinical course and 80% were incontinent. There was circumferential meningeal fibrosis with concomitant focal, malacic, destruction of the neuroparenchyma in the thoracolumbar spinal cord in 24/30 pugs. Vertebral lesions accompanied the focal spinal cord lesion, and there was lympho-histiocytic inflammation associated or not to the parenchymal lesion in 43% of the pugs. CONCLUSIONS AND CLINICAL IMPORTANCE Meningeal fibrosis with associated focal spinal cord destruction and neighboring vertebral column lesions were common findings in pugs with long-standing thoracolumbar myelopathy.

中文翻译：

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哈巴狗胸腰部脑膜纤维化。

背景技术在哈巴狗中发生与脊髓和椎骨病变相关的胸腰椎病，具有相似的临床表型，但是潜在的病因不同。目的进一步鉴定长期存在胸腰段脊髓病的哈巴狗的临床和神经病理学特征。动物该研究包括30个客户拥有的纯种哈巴狗，它们有一个多月的共济失调和骨盆四肢麻痹的病史，这表明该病局限于胸腰段脊髓。方法进行前瞻性临床病理研究。包括的哈巴狗均接受了完整的神经系统检查，并以脊髓为重点进行了大体和组织病理学死后研究。计算机断层扫描（n = 18），磁共振成像（n = 17），死亡前或死亡后进行脑脊液分析（n = 27）。结果二十只雄性和十只雌性哈巴狗在临床发病时的中位年龄为84个月（四分位间距为66-96）。受影响的哈巴狗出现了渐进的临床病历，其中80％的尿失禁。24/30帕格在胸腰段脊髓中伴有局灶性，苹果性，脑实质破坏，伴有周围性脑膜纤维化。椎骨病变伴有局灶性脊髓病变，并且在43％的哈巴狗中存在与实质性病变相关或无关的淋巴组织炎。结论和临床意义在伴有长期胸腰段脊髓病的哈巴狗中，脑膜纤维化伴有局灶性脊髓破坏和邻近的脊柱病变是常见的发现。