BACKGROUND Childhood maltreatment is associated with major depressive disorder (MDD). It not only increases the risk of lifetime MDD, but it also aggravates its course. Among depressed patients, 20-30% of them experience treatment-resistance depression (TRD). We aimed to assess the association between childhood maltreatment, severity of depression in a unipolar TRD sample, and patient outcomes after one-year of follow-up. METHODS Patients were recruited for a prospective cohort from the French network of TRD expert centers. Depressive symptom severity was assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Quick Inventory of Depressive Symptomatology self-report (QIDS-SR). Childhood maltreatment was evaluated with the Childhood Trauma Questionnaire (CTQ). RESULTS In total, 256 patients filled in the CTQ at baseline between 2012 and 2019. At baseline, the MADRS score was associated with CTQ score (β = .185; p = .004). QIDS was also associated with CTQ scores (β = .27; p < .001). Regarding the different subtypes of childhood maltreatment, MADRS was associated with physical (β = .21; p = .005) and sexual abuse (β = .22; p = .002), while QIDS with physical abuse (β = .304; p < .001) and physical neglect (β = .254; p < .001). However, we did not find any significant association focusing on the other types of traumas. During a 1-year follow-up focusing on remission, CTQ scores (baseline) were less important in remittent patients [n = 38; CTQ score = 39.26 (9.68)] than in nonremittent ones [n = 92; CTQ score = 46.02 (17.53)] (p = .027). There was no significant difference among remitters and nonremitters based on trauma subtypes. At baseline, CTQ scores had a significant influence on remission at 1 year (χ2 (1) = 5.57; p < .05). We lost this influence adding MADRS scores at baseline in the model (p = .063). CONCLUSION We highlighted a significant association between the severity of depressive disorders and childhood maltreatment in the TRD population. Information about a history of childhood maltreatment helps in identifying individuals who could be less likely to go into remission after treatment.

中文翻译：

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法国门诊队列中的儿童期虐待和难治性抑郁症的临床严重性（FACE-DR）：一年随访。

背景技术儿童期虐待与重度抑郁症（MDD）有关。它不仅增加了终生MDD的风险，而且加剧了其进程。在抑郁症患者中，其中20％至30％患有抗药性抑郁症（TRD）。我们旨在评估儿童期虐待，单极性TRD样本中抑郁症的严重程度以及一年的随访后患者预后之间的关联。方法从法国TRD专家中心网络招募患者进行前瞻性队列研究。抑郁症状的严重程度通过Montgomery-Åsberg抑郁评分量表（MADRS）和抑郁症状自我报告快速清单（QIDS-SR）进行评估。通过《儿童创伤调查表》（CTQ）评估了儿童虐待情况。结果总计 在2012年至2019年之间，共有256位患者在基线时填写了CTQ。基线时，MADRS得分与CTQ得分相关（β= .185； p = .004）。QIDS也与CTQ评分相关（β= .27； p <.001）。关于儿童虐待的不同亚型，MADRS与身体虐待（β= .21; p = .005）和性虐待（β= .22; p = .002）相关，而QIDS与身体虐待有关（β= .304; p <.001）和身体上的疏忽（β= .254; p <.001）。但是，我们没有发现与其他类型的创伤有关的显着关联。在以缓解为中心的为期1年的随访中，CTQ得分（基线）在缓解患者中的重要性较轻[n = 38; CTQ分数= 39.26（9.68）]，比非汇款者[n = 92; CTQ分数= 46.02（17.53）]（p = .027）。根据创伤亚型的情况，汇款人和非汇款人之间没有显着差异。在基线时，CTQ分数对1年的缓解有显着影响（χ2（1）= 5.57； p <.05）。我们在模型的基线处增加了MADRS分数，就失去了这种影响力（p = .063）。结论我们强调了TRD人群中抑郁症的严重程度与儿童期虐待之间的显着相关性。有关儿童时期虐待史的信息有助于确定在治疗后不太可能缓解的个体。结论我们强调了TRD人群中抑郁症的严重程度与儿童期虐待之间的显着相关性。有关儿童时期虐待史的信息有助于确定在治疗后不太可能缓解的个体。结论我们强调了TRD人群中抑郁症的严重程度与儿童期虐待之间的显着相关性。有关儿童时期虐待史的信息有助于确定在治疗后不太可能缓解的个体。