Four 2-month-old foals were presented to an equine hospital with acute kidney injury caused by Leptospira interrogans infection. Clinical signs were nonspecific and included lethargy, fever, and unwillingness to nurse. The most important hematologic and clinicopathologic findings were azotemia, anemia, thrombocytopenia, hyponatremia, and hypochloremia. The diagnosis was based on urinary real-time PCR, serology using a microscopic agglutination test, or both. The most important serovars involved were L. interrogans serogroup australis serovar Bratislava and Australis. Treatment consisted of IV fluid therapy and antimicrobial treatment. Renal replacement therapy with hemodiafiltration was performed in 1 of the foals. All foals survived to discharge. This report highlights the importance of early diagnosis and treatment in foals with acute kidney injury caused by L. interrogans infection.

中文翻译：

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4只小马驹因钩端螺旋体引起的急性肾脏损伤，1只小马驹使用肾替代疗法并伴有间歇性血液透析滤过。

将四只2个月大的小马驹送至一间马医院，该医院因问号钩端螺旋体感染引起急性肾损伤。临床体征是非特异性的，包括嗜睡，发烧和不愿护理。血液学和临床病理学最重要的发现是氮质血症，贫血，血小板减少症，低钠血症和低氯血症。诊断基于尿液实时PCR，使用显微镜凝集试验的血清学或两者。涉及的最重要的血清型是问号乳杆菌血清群，澳大利亚血清型，布拉迪斯拉发和南极。治疗包括静脉输液治疗和抗菌治疗。在其中的一只小马中进行了具有血液透析滤过的肾脏替代治疗。所有小马驹幸免于难。