Spinal cord injury (SCI) is the major cause of the spinal damage affecting motor and sensory function. Thus, the present study was conducted to investigate the effect of D-pinitol (PN) on spinal cord injury in rats. The PN showed to recover motor function near to normal via modulating oxidative stress, inflammatory response and cellular apoptosis in SCI rats. PN also causes modulation of Bcl2 family proteins and reduces the level of NF-ĸB and LOX-1 in dose dependent manner. The PN causes reduction of NLRP3, TNF-α and iNOS, with increase in caspase-1 together with modulation of MAPK mediators. It has been suggested that, D-pinitol exert protective action against SCI via inhibition of apoptosis, inflammation and oxidative stress, via modulating Bcl-2 genes and MAPK pathway.

中文翻译：

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D-松醇对大鼠实验性脊髓损伤的保护作用。

脊髓损伤（SCI）是影响运动和感觉功能的脊髓损伤的主要原因。因此，本研究旨在探讨D-松醇（PN）对大鼠脊髓损伤的影响。PN 通过调节 SCI 大鼠的氧化应激、炎症反应和细胞凋亡，使运动功能恢复接近正常。PN 还会引起 Bcl2 家族蛋白的调节，并以剂量​​依赖性方式降低 NF-κB 和 LOX-1 的水平。PN 导致 NLRP3、TNF-α 和 iNOS 减少，同时 caspase-1 增加以及 MAPK 介质的调节。研究表明，D-pinitol 通过调节 Bcl-2 基因和 MAPK 通路，抑制细胞凋亡、炎症和氧化应激，发挥对 SCI 的保护作用。