BACKGROUND Programmable differential pressure (DP) valves combined with an anti-siphon device (ASD) represent the current standard of care in preemtping overdrainage associated with ventriculoperitoneal shunting for hydrocephalus. OBJECTIVE We aimed to provide comparative data of four combinations of two ASDs of different working principles in combination with two DP valves in an in vitro model in order to achieve a better understanding of the flow characteristics and potential clinical application. METHODS We analyzed the flow performance of four possible combinations of two DP valves (CHPV [HM]; proGAV 2.0[PG]) in combination with either a gravity-regulated (Shuntassistant [SA]) or a flow-regulated (SiphonGuard [SG]) ASD in an in vitro setup. A DP between 4 and 60 cmH2O was generated, and the specific flow characteristics were measured. In addition, the two combinations with gravity-regulated ASDs were measured in defined spatial positions. RESULTS Flow characteristics of the SA combinations corresponded to the DP in linear fashion and to the spatial position. Flow characteristics of the SG combinations were dependent upon the DP in a non-linear fashion and independent of the spatial position. Highest mean flow rate of the PG-SG- (HM-SG-) combination was 1.41 ± 0.24 ml/min (1.16 ± 0.06 ml/min). The mean flow rates sharply decreased with increasing inflow pressure and subsequently increased slowly up to 0.82 ± 0.26 ml/min (0.77 ± 0.08 ml/min). CONCLUSION All tested device combinations were able to control hydrostatic effect and prevent consecutive excessive flow, to varying degrees. However, significant differences in flow characteristics can be seen, which might be relevant for their clinical application.

中文翻译：

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相对于空间位置，防虹吸装置与差压阀组合的体外性能。

背景技术与防虹吸装置（ASD）结合的可编程差压（DP）阀代表了在预埋与脑室-腹膜分流相关的脑积水相关的过度排水的当前护理标准。目的我们旨在在体外模型中提供两种不同工作原理的ASD与四个DP阀组合的四种组合的比较数据，以便更好地了解血流特性和潜在的临床应用。方法我们分析了两种DP阀（CHPV [HM]； proGAV 2.0 [PG]）与重力调节（Shuntassistant [SA]）或流量调节（SiphonGuard [SG]）组合的四种可能的流动性能。 ）体外设置的ASD。产生介于4和60 cmH2O之间的DP，并测量了比流动特性。此外，在限定的空间位置上测量了两种具有重力调节ASD的组合。结果SA组合的流动特性与DP呈线性关系并与空间位置相对应。SG组合的流动特性以非线性方式取决于DP，并且与空间位置无关。PG-SG-（HM-SG-）组合的最高平均流速为1.41±0.24 ml / min（1.16±0.06 ml / min）。随着流入压力的增加，平均流速急剧下降，随后缓慢上升至0.82±0.26 ml / min（0.77±0.08 ml / min）。结论所有测试的设备组合均能够控制静水效果并在不同程度上防止连续的过大流量。但是，可以看到流动特性存在明显差异，