We evaluated the protein and energy intakes of infants fed commercial infant Formula A (protein, 2.2 g/100 kcal; energy, 68 kcal/100 mL) and examined whether changes in feeding intervals are involved in constant energy intake. Daily nutritional intake of 378 Formula A-fed infants was assessed using reference values and compared to that of infants fed Formulas B (protein: 2.3 g/100 kcal, energy: 68 kcal/100 mL) and C (protein: 2.4 g/100kcal, energy: 70 kcal/100 mL). From 15 to 149 days of age, the mean formula volume and protein intake were 758-887 mL/day and 11.4-13.3 g/day, respectively, higher than the protein intake of breast-fed infants. Daily energy intake (86-129 kcal/kg/day) was comparable to the estimated energy requirements. Feeding intervals were shorter in infants fed Formulas A and B than in those fed Formula C, whereas energy intake was similar. The protein intake of infants decreased as the protein concentration per energy in infant formula was reduced, and accordingly the protein intake of Formula A-fed infants was significantly lower than that of Formula C-fed infants. In conclusion, the new composition of Formula A is suitable in protein and energy intake of infants, and daily energy intake remains constant by shortening in feeding intervals when the energy concentration in infant formula is reduced.Clinical Trial Registration: UMIN000023110.

中文翻译：

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用降低的蛋白质浓度为2.2 g / 100 kcal的商业婴儿配方奶粉喂养的婴儿，其每日蛋白质和能量摄入量：喂养间隔对能量摄入量的影响。

我们评估了喂食市售婴儿配方奶粉的婴儿的蛋白质和能量摄入（蛋白质2.2 g / 100 kcal；能量68 kcal / 100 mL），并检查了喂养间隔的变化是否与恒定的能量摄入有关。使用参考值评估了378名由配方A喂养的婴儿的每日营养摄入量，并将其与以配方B（蛋白质：2.3 g / 100 kcal，能量：68 kcal / 100 mL）和C（蛋白质：2.4 g / 100kcal）喂养的婴儿进行了比较。 ，能量：70 kcal / 100 mL）。从15到149天，平均配方奶量和蛋白质摄入量分别为758-887 mL /天和11.4-13.3 g /天，高于母乳喂养婴儿的蛋白质摄入量。每天的能量摄入（86-129 kcal / kg /天）与估计的能量需求相当。喂养配方奶A和B的婴儿的喂养间隔比喂养配方奶C的婴儿更短，而能量摄入是相似的。随着婴儿配方食品中每能量蛋白质浓度的降低，婴儿的蛋白质摄入量减少，因此，由配方A喂养的婴儿的蛋白质摄入量显着低于由配方C喂养的婴儿。总之，新配方的A配方适合婴儿的蛋白质和能量摄入，当降低婴儿配方食品中的能量浓度时，可以通过缩短喂食间隔来保持每日的能量摄入恒定。临床试验注册：UMIN000023110。