当前位置: X-MOL 学术Curr. Topics Med. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Recent Development of 1,2,4-triazole-containing Compounds as Anticancer Agents.
Current Topics in Medicinal Chemistry ( IF 3.4 ) Pub Date : 2020-05-31 , DOI: 10.2174/1568026620666200128143230
Xiaoyue Wen 1 , Yongqin Zhou 1 , Junhao Zeng 1 , Xinyue Liu 1
Affiliation  

1,2,4-Triazole derivatives possess promising in vitro and in vivo anticancer activity, and many anticancer agents such as fluconazole, tebuconazole, triadimefon, and ribavirin bear a 1,2,4-triazole moiety, revealing their potential in the development of novel anticancer agents. This review emphasizes the recent advances in 1,2,4-triazole-containing compounds with anticancer potential, and the structureactivity relationships as well as mechanisms of action are also discussed.



中文翻译:

含1,2,4-三唑的化合物作为抗癌药的最新进展。

1,2,4-三唑衍生物具有令人满意的体内和体外抗癌活性,许多抗癌药(例如氟康唑,戊唑醇,三唑酮和利巴韦林)带有1,2,4-三唑部分,从而揭示了它们在开发中的潜力。新型抗癌药。这篇综述强调具有抗癌潜力的含1,2,4-三唑的化合物的最新进展,并且还讨论了结构活性关系以及作用机理。

更新日期:2020-07-22
down
wechat
bug