Most breast cancer survivors receiving chemotherapy have severe cognitive impairment, often referred to as "chemobrain." Polydatin (PLD) is known to have many biological activities. Thus, this study aimed to determine whether symptoms of chemobrain can be prevented or relieved by PLD. The chemobrain models were established by intraperitoneal injection of doxorubicin (DOX, 2 mg/kg) in rats once a week for 4 weeks (DOX group and DOX+PLD group). In the PLD group and DOX+PLD group, PLD (50 mg/kg) was administered orally to rats every day. We found that PLD treatment significantly protected against DOX-induced learning and memory impairment, restored hippocampal histopathological architecture. Furthermore, PLD suppressed DOX-induced oxidative stress through up-regulating Nrf2, inhibited inflammatory response by activating the NF-κB pathway, and reduced hippocampal apoptosis. Therefore, the present study indicated that PLD offered neuroprotection against DOX-induced chemobrain. PLD may assist in preventing chemobrain after chemotherapy in patients with cancers.

中文翻译：

---

多肽抑制大鼠的氧化应激，炎症反应和细胞凋亡，从而改善化学疗法引起的认知障碍（chemobrain）。

大多数接受化疗的乳腺癌幸存者都患有严重的认知障碍，通常被称为“化学障碍”。已知polydatin（PLD）具有许多生物活性。因此，本研究旨在确定PLD是否可以预防或缓解化学障碍症状。通过每周一次在大鼠中腹膜内注射阿霉素（DOX，2 mg / kg）建立化学障碍模型，持续4周（DOX组和DOX + PLD组）。在PLD组和DOX + PLD组中，每天对大鼠口服PLD（50mg / kg）。我们发现PLD治疗显着保护DOX诱导的学习和记忆障碍，恢复海马组织病理学结构。此外，PLD通过上调Nrf2抑制DOX诱导的氧化应激，通过激活NF-κB途径抑制炎症反应，并减少海马凋亡。因此，本研究表明PLD提供了针对DOX诱导的化学障碍的神经保护作用。PLD可能有助于预防癌症患者化疗后的脑梗塞。