Introduction: 

Studies have demonstrated an inverse relationship between Alzheimer dementia (AD) and cancer. This inverse relationship was further explored. In addition, Pin1 expression has been implicated in the cell cycle regulation of both disease processes. The relationship of Pin1 expression in 10 cancer types and secondary diagnosis of AD was examined.

Materials and Methods: 

A cross-sectional analysis was performed using discharge data from the National Inpatient Sample from 1999 to 2008. Cancer was defined as the primary discharge diagnosis and AD was defined as the secondary discharge diagnosis. Cancer types were grouped according to their Pin1 expression to examine its relationship with AD. Analysis was performed by logistic regression.

Results: 

Of ∼3 million cancer discharge diagnoses, 1.0% had a secondary diagnosis of AD. Discharge data of all 10 cancer types revealed a lower likelihood of secondary AD diagnosis. Prostate [crude odds ratios (OR): 0.26 (0.24 to 0.29), multivariate OR: 0.39 (0.35 to 0.43)], ovarian [crude OR: 0.38 (0.32 to 0.44), multivariate OR: 0.35 (0.30 to 0.41)], and lung cancer [crude OR: 0.39 (0.36 to 0.41), multivariate OR: 0.41 (0.39 to 0.44)] demonstrated the lowest odds of secondary AD diagnosis. When cancer types were grouped per Pin1 expression, cancer types with Pin1 underexpression were more likely to be associated with secondary diagnosis of AD than cancer types with Pin1 overexpression [crude OR: 1.4 (1.3 to 1.4), multivariate OR: 1.08 (1.02 to 1.14)].

Discussion: 

This secondary data analysis further demonstrated an inverse relationship between AD and 10 cancer types, with prostate, ovarian, and lung cancers displaying the greatest inverse relationship. Pin1 underexpressing cancer types had a significantly higher likelihood of secondary diagnosis of AD than Pin1 overexpressing cancer types.

中文翻译：

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阿尔茨海默氏病和癌症：全国住院患者样本分析。

介绍： 

研究表明，阿尔茨海默氏痴呆症（AD）与癌症之间存在反比关系。这种反比关系得到了进一步的探索。此外，Pin1表达已牵涉到两种疾病过程的细胞周期调控中。检查了Pin1在10种癌症类型中的表达与AD继发诊断的关系。

材料和方法： 

使用1999年至2008年国家住院样本的出院数据进行横断面分析。癌症被定义为主要出院诊断，AD被定义为次要出院诊断。根据其Pin1表达对癌症类型进行分组，以检查其与AD的关系。通过逻辑回归进行分析。

结果： 

在约300万例癌症出院诊断中，有1.0％对AD进行了辅助诊断。所有10种癌症类型的出院数据表明，进行二次AD诊断的可能性较低。前列腺[原油比值比（OR）：0.26（0.24至0.29），多元OR：0.39（0.35至0.43）]，卵巢[原油OR：0.38（0.32至0.44），多元OR：0.35（0.30至0.41）]，和肺癌[粗OR：0.39（0.36〜0.41），多元OR：0.41（0.39〜0.44）]证实二次AD诊断的最低可能性。当癌症类型中每分组中Pin1表达，癌症类型的具有中Pin1表达不足更可能与AD的比仲诊断相关Pin1过表达的癌症类型[粗OR：1.4（1.3至1.4），多变量OR：1.08（1.02至1.14）]。

讨论： 

此辅助数据分析进一步证明了AD与10种癌症类型之间存在反比关系，其中前列腺癌，卵巢癌和肺癌显示出最大的反比关系。PIN1不足的癌症类型具有AD的辅助诊断的显著较高可能性比PIN1过表达的癌症的类型。