Understanding how the four-chambered mammalian heart is formed from a simple, looped tube remains challenging, notwithstanding the descriptive accounts left by generations of cardiac anatomists. Much of the difficulty lies in attempting to visualize an intricate series of morphological transformations through the restrictive lens of two-dimensional images derived from histology. Modern imaging methods offer a way to overcome this limitation by providing comprehensive and high-resolution image sets of the developing heart. We have used one such method, high-resolution episcopic microscopy (HREM), to obtain virtual three-dimensional (3D) models of successive stages in mouse heart development. Taking advantage of the ability afforded by 3D modeling to view each heart in any orientation or erosion plane, we provide an illustrated account of how the mouse heart divides into left and right ventricular chambers, and how each acquires its own distinct outflow vessel.

中文翻译：

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发育中心脏的 3D 解剖：了解心室间隔。

尽管几代心脏解剖学家留下了描述性的描述，但了解哺乳动物的四腔心脏是如何由一个简单的环状管形成的仍然具有挑战性。大部分困难在于试图通过源自组织学的二维图像的限制性镜头来可视化一系列错综复杂的形态学变化。现代成像方法通过提供发育中心脏的全面和高分辨率图像集，提供了一种克服这一限制的方法。我们使用了一种这样的方法，即高分辨率反射显微镜 (HREM)，以获得小鼠心脏发育连续阶段的虚拟三维 (3D) 模型。利用 3D 建模提供的能力以任何方向或侵蚀平面查看每颗心脏，