ABSTRACT

Introduction: Cost-of-illness studies are widely used for healthcare decision-making; however, no such study is available in pemphigus from the societal perspective. The purpose of this analysis was to estimate annual cost-of-illness per patient with pemphigus from a societal perspective.

Areas covered: Between 2014 and 2017, a multicenter, cross-sectional study was carried out. Consecutive pemphigus patients aged ≥18 years were recruited at all four university dermatology departments in Hungary. Direct and indirect costs were calculated, including costs for treatments, outpatient visits, hospital admissions, informal care, travel costs and productivity loss. Generalized linear model was used to analyze predictors of costs. Atotal of 109 patients with pemphigus enrolled with amean age of 57.1 (SD 14.8) years. Total cost per pemphigus patient was €3,995 (SD €7,526) peryear, with productivity loss (58%) and informal care (19%) accounting for the majority. Annual means of 189 and 41 working hours were lost due to absence from work and reduced productivity, respectively. Younger age and pemphigus vulgaris were associated with higher costs (p < 0.05).

Expert opinion: This is the first cost-of-illness study applying the societal perspective in pemphigus. Our results indicate a substantial economic burden on society, mainly driven by productivity loss and informal care.

摘要

简介：疾病成本研究被广泛用于医疗保健决策；但是，从社会的角度来看，天疱疮尚无此类研究。这项分析的目的是从社会角度估计每名天疱疮患者的年度疾病费用。

覆盖区域：在2014年至2017年期间，进行了一项多中心的横截面研究。在匈牙利的所有四个大学皮肤科中招募了连续性≥18岁的天疱疮患者。计算了直接和间接费用，包括治疗，门诊就诊，住院费用，非正式护理，旅行费用和生产力损失的费用。广义线性模型用于分析成本预测因素。109名天疱疮患者的总登记年龄为57.1（SD 14.8）岁。每年每名天疱疮患者的总费用为3,995欧元（合SD 7,526欧元），其中生产力损失（58％）和非正式护理（19％）占大多数。由于缺勤和生产力下降，每年平均损失189和41个工作小时。年龄越小和寻常型天疱疮的发生率越高（p <0。

专家意见：这是第一个将社会视角应用于天疱疮的疾病成本研究。我们的结果表明，社会的重大经济负担主要是生产力下降和非正式护理所致。