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Design and Evaluation of a Novel Laminectomy Auxiliary Device Based on Rats.
IEEE Transactions on Neural Systems and Rehabilitation Engineering ( IF 4.9 ) Pub Date : 2020-01-22 , DOI: 10.1109/tnsre.2020.2968610
Xiao-Hua Zhou , Wen-Tao Li , Bo-Lun Zhao , Zhu-Ren Bao , Chang-Hong Liu , Su-Qian Wu , Hong-Xia Xue , Yan-Bing Liu , Cui-Hua Han , Jiao Wang , Li-Bin An

Most types of spinal cord injury (SCI) observed in humans can be replicated in adult rat models, which are widely used for laboratory studies of SCI rehabilitation. To ensure the effectiveness and efficiency of an SCI rat model, the minimal time spent performing the laminectomy procedure and the damage caused to the body are of great importance. We describe and evaluate the effectiveness and advantages of a laminectomy auxiliary device (LAD) for removing the rat vertebral lamina without injuring the spinal cord. The incision size, success rate, operation duration, body weight, BBB score, step detection, latency and amplitude of transcranial electrical motor-evoked potentials (tceMEPs), and serum MDA and SOD levels were recorded in 8 normal rats, 8 rats treated with traditional laminectomy and 8 rats treated with LAD laminectomy. Compared with traditional laminectomy, in our LAD, the surgical incision was smaller (approximately 2.2 and 1.3 cm, respectively), the success rate was higher (88.89% and 100%, respectively) and the duration shorter (14.644±1.617 and 4.821±0.668 minutes, respectively). Compared with normal rats, those treated with either laminectomy using LAD or the traditional method showed slower body weight gain and temporarily increased oxidative stress levels. However, there were no significant differences between these two groups. Our results show that laminectomy using this LAD provides three main advantages in rats: a high success rate, time savings, small incisions and reduced trauma. We believe this LAD can be used as an effective assistant tool for rodent laminectomy.

中文翻译:

基于大鼠的新型椎板切除术辅助装置的设计与评估。

在人类中观察到的大多数类型的脊髓损伤(SCI)均可在成年大鼠模型中复制,该模型已广泛用于SCI康复的实验室研究。为了确保SCI大鼠模型的有效性和效率,执行椎板切除术所需的最少时间以及对身体造成的损害至关重要。我们描述和评估椎板切除术辅助装置(LAD)的功效和优势,以在不损伤脊髓的情况下去除大鼠椎板。在8例正常大鼠中,记录了切口的大小,成功率,手术持续时间,体重,BBB评分,台阶检测,潜伏期和经颅电机电动诱发电位(tceMEPs)的幅度以及血清MDA和SOD水平,其中8例大鼠接受了传统的椎板切除术和8只大鼠行LAD椎板切除术。与传统的椎板切除术相比,在我们的LAD中,手术切口更小(分别约为2.2和1.3 cm),成功率更高(分别为88.89%和100%)并且持续时间更短(14.644±1.617和4.821±0.668)分钟)。与正常大鼠相比,使用LAD或常规方法进行椎板切除术治疗的大鼠体重增加较慢,氧化应激水平暂时升高。但是,这两组之间没有显着差异。我们的结果表明,使用这种LAD的椎板切除术在大鼠中提供了三个主要优点:成功率高,节省时间,切口小,创伤小。我们相信这种LAD可以用作啮齿动物椎板切除术的有效辅助工具。分别为2和1.3厘米),成功率更高(分别为88.89%和100%),持续时间更短(分别为14.644±1.617和4.821±0.668分钟)。与正常大鼠相比,使用LAD或常规方法进行椎板切除术治疗的大鼠体重增加较慢,氧化应激水平暂时升高。但是,这两组之间没有显着差异。我们的结果表明,使用这种LAD的椎板切除术在大鼠中提供了三个主要优点:成功率高,节省时间,切口小,创伤小。我们相信这种LAD可以用作啮齿动物椎板切除术的有效辅助工具。分别为2和1.3厘米),成功率更高(分别为88.89%和100%),持续时间更短(分别为14.644±1.617和4.821±0.668分钟)。与正常大鼠相比,使用LAD或常规方法进行椎板切除术治疗的大鼠体重增加较慢,氧化应激水平暂时升高。但是,这两组之间没有显着差异。我们的结果表明,使用这种LAD的椎板切除术在大鼠中提供了三个主要优点:成功率高,节省时间,切口小,创伤小。我们相信这种LAD可以用作啮齿动物椎板切除术的有效辅助工具。使用LAD或常规方法进行椎板切除术的患者显示出较慢的体重增加并暂时增加了氧化应激水平。但是,这两组之间没有显着差异。我们的结果表明,使用这种LAD的椎板切除术在大鼠中提供了三个主要优点:成功率高,节省时间,切口小,创伤小。我们相信这种LAD可以用作啮齿动物椎板切除术的有效辅助工具。使用LAD或常规方法进行椎板切除术治疗的患者体重增加较慢,氧化应激水平暂时升高。但是,这两组之间没有显着差异。我们的结果表明,使用这种LAD的椎板切除术在大鼠中提供了三个主要优点:成功率高,节省时间,切口小,创伤小。我们相信这种LAD可以用作啮齿动物椎板切除术的有效辅助工具。小切口,减少创伤。我们相信这种LAD可以用作啮齿动物椎板切除术的有效辅助工具。小切口,减少创伤。我们相信这种LAD可以用作啮齿动物椎板切除术的有效辅助工具。
更新日期:2020-03-20
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