Both innate and adaptive immune responses of host are regulated by fine balance between negative and positive signals to ensure their termination and onset on entry of pathogens. Suppressor of cytokine signaling (SOCS) genes inhibit cytokine signaling pathways and regulate innate and adaptive immunity. SOCS genes perform their function by positive and negative regulation of macrophages, development and differentiation of T cells, and activation of dendritic cells. Although the role of SOCS1 and SOCS3 genes in hepatitis C virus (HCV) patients has been well studied, the correlation of SOCS1 gene expression with complete blood count in HCV-positive patients has not been established yet. We observed a weak positive correlation of SOCS1 gene expression with hemoglobin (Hb) and platelet count, whereas leukocytes were negatively correlated with the expression. This study also provides a comparative analysis of complete blood count between healthy subjects and HCV-positive subjects. The findings suggest that Hb and platelet count were significantly lower (P < 0.0001) in HCV patients than in healthy subjects.

中文翻译：

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血细胞与丙型肝炎病毒感染患者细胞因子信号转导基因表达抑制的临床相关性。

宿主的先天性和适应性免疫反应都受到负信号和正信号之间的精细平衡的调节，以确保它们在病原体进入时终止和开始。细胞因子信号传导抑制基因 (SOCS) 基因抑制细胞因子信号通路并调节先天性和适应性免疫。SOCS 基因通过巨噬细胞的正负调节、T 细胞的发育和分化以及树突细胞的激活来发挥其功能。尽管 SOCS1 和 SOCS3 基因在丙型肝炎病毒 (HCV) 患者中的作用已得到充分研究，但尚未确定 SOCS1 基因表达与 HCV 阳性患者全血细胞计数的相关性。我们观察到 SOCS1 基因表达与血红蛋白 (Hb) 和血小板计数呈弱正相关，而白细胞与表达呈负相关。该研究还提供了健康受试者和 HCV 阳性受试者之间全血细胞计数的比较分析。研究结果表明，HCV 患者的 Hb 和血小板计数显着低于健康受试者（P < 0.0001）。