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Evaluation of baseline fracture risk in younger postmenopausal women with breast cancer using different risk assessment methods.
Skeletal Radiology ( IF 2.1 ) Pub Date : 2020-01-24 , DOI: 10.1007/s00256-020-03378-z
Dagmar Schaffler-Schaden 1 , Christoph Kneidinger 2 , Gregor Schweighofer-Zwink 2 , Maria Flamm 1 , Bernhard Iglseder 3 , Christian Pirich 2
Affiliation  

OBJECTIVE Controversy exists about the impact of bone mineral density (BMD) and fracture risk in newly diagnosed patients with breast cancer (BC). It is presumed that there are differences in BMD between women with BC and healthy controls. BMD is therefore considered as a potential marker to predict BC risk. This study was conducted to investigate the association of BMD, trabecular bone score (TBS) and fracture risk in younger postmenopausal women with hormone responsive BC. METHODS Overall, 343 women were examined. Women with BC were matched to a control group of the general population. Forty-nine women and fifty-nine controls were included in the final analysis. All subjects underwent dual energy x-ray absorptiometry (DXA) of the lumbar spine, femoral neck, and the total hip to evaluate bone mineral density. The 10-year fracture risk for a major osteoporotic fracture was assessed using the FRAX-score and the TBS-adjusted FRAX-Score, respectively. RESULTS Lumbar and femoral neck BMD were similar in BC patients and controls. No difference was found for TBS of the spine (1.38 ± 0.1 vs.1.36 ± 0.09) in the BC and the control group, respectively (p = 0.19). The 10- year probability for a major osteoporotic fracture (MoF) or femoral neck (FN) fracture was 6.1 (± 2.6%) and 0.9 (± 1.2%) in the BC group vs. 6.7 (± 3.5%) (p = 0.33) and 0.9 (± 1.1%) (p = 0.73) in the control group. CONCLUSION Postmenopausal women younger than 60 years with breast cancer do not show any differences in baseline BMD, TBS, or TBS adjusted FRAX in comparison to controls.

中文翻译:

使用不同的风险评估方法评估绝经后年轻乳腺癌女性的基线骨折风险。

目的关于新诊断的乳腺癌(BC)患者的骨矿物质密度(BMD)和骨折风险的影响存在争议。据推测,BC女性与健康对照者之间的BMD存在差异。因此,BMD被认为是预测BC风险的潜在标志。这项研究的目的是研究激素反应性BC的年轻绝经后女性的BMD,小梁骨评分(TBS)与骨折风险之间的关系。方法总共检查了343名女性。患有BC的女性与普通人群的对照组相匹配。最终分析中包括49名妇女和59名对照。所有受试者均接受腰椎,股骨颈和整个髋部的双能X线骨密度仪(DXA)评估骨矿物质密度。分别使用FRAX评分和TBS调整后的FRAX评分评估了主要骨质疏松性骨折的10年骨折风险。结果BC患者和对照组的腰椎和股骨颈BMD相似。在BC组和对照组中,脊柱的TBS均无差异(1.38±0.1 vs 1.36±0.09)(p = 0.19)。BC组发生重大骨质疏松性骨折(MoF)或股骨颈(FN)骨折的10年可能性为6.1(±2.6%)和0.9(±1.2%),而BC组为6.7(±3.5%)(p = 0.33 )和对照组的0.9(±1.1%)(p = 0.73)。结论年龄小于60岁的绝经后乳腺癌女性与对照组相比,基线BMD,TBS或TBS调整后的FRAX没有任何差异。结果BC患者和对照组的腰椎和股骨颈BMD相似。在BC组和对照组中,脊柱的TBS均无差异(1.38±0.1 vs 1.36±0.09)(p = 0.19)。BC组发生重大骨质疏松性骨折(MoF)或股骨颈(FN)骨折的10年可能性为6.1(±2.6%)和0.9(±1.2%),而BC组为6.7(±3.5%)(p = 0.33 )和对照组的0.9(±1.1%)(p = 0.73)。结论年龄小于60岁的乳腺癌绝经后妇女与对照组相比,基线BMD,TBS或TBS调整后的FRAX没有任何差异。结果BC患者和对照组的腰椎和股骨颈BMD相似。在BC组和对照组中,脊柱的TBS均无差异(1.38±0.1 vs 1.36±0.09)(p = 0.19)。BC组发生重大骨质疏松性骨折(MoF)或股骨颈(FN)骨折的10年可能性为6.1(±2.6%)和0.9(±1.2%),而BC组为6.7(±3.5%)(p = 0.33 )和对照组的0.9(±1.1%)(p = 0.73)。结论年龄小于60岁的绝经后乳腺癌女性与对照组相比,基线BMD,TBS或TBS调整后的FRAX没有任何差异。BC组发生重大骨质疏松性骨折(MoF)或股骨颈(FN)骨折的10年可能性为6.1(±2.6%)和0.9(±1.2%),而BC组为6.7(±3.5%)(p = 0.33 )和对照组的0.9(±1.1%)(p = 0.73)。结论年龄小于60岁的绝经后乳腺癌女性与对照组相比,基线BMD,TBS或TBS调整后的FRAX没有任何差异。BC组发生重大骨质疏松性骨折(MoF)或股骨颈(FN)骨折的10年可能性为6.1(±2.6%)和0.9(±1.2%),而BC组为6.7(±3.5%)(p = 0.33 )和对照组的0.9(±1.1%)(p = 0.73)。结论年龄小于60岁的乳腺癌绝经后妇女与对照组相比,基线BMD,TBS或TBS调整后的FRAX没有任何差异。
更新日期:2020-04-22
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