Clinically node-positive prostate cancer is often found at the time of diagnosis by cross-sectional imaging and remains poorly understood. Advanced imaging modalities such as magnetic resonance imaging nanoparticles or positron emission tomography-based molecular imaging stand to rapidly change the field and hopefully will bring better diagnostic clarity. This will allow for prospective clinical trials using radiographic, clinical, or molecular parameters to establish who may benefit from both localized and systemic treatment intensification and who may avoid overtreatment. Recent advances in metastatic hormone-sensitive disease may offer clues, but direct studies for nodal disease patients remain.

中文翻译：

---

临床淋巴结阳性前列腺癌：在局灶性和全身性疾病控制的交叉点。

临床上淋巴结阳性的前列腺癌通常在诊断时通过横截面成像发现，并且了解甚少。诸如磁共振成像纳米颗粒或基于正电子发射断层扫描的分子成像等先进的成像方法有望迅速改变这一领域，并有望带来更好的诊断清晰度。这将允许使用射线照相，临床或分子参数进行前瞻性临床试验，以确定谁可能会从局部和全身治疗强化中受益，以及谁可能会避免过度治疗。转移性激素敏感性疾病的最新进展可能提供一些线索，但仍然存在针对淋巴结病患者的直接研究。