BACKGROUND Feline parvovirus (FPV) is a common and potentially lethal infectious agent in cats. OBJECTIVE To assess the prognostic value of age, neuter status, serum concentrations of serum amyloid A (SAA), haptoglobin, cholesterol and total thyroxine (tT4), and the presence of systemic inflammatory response syndrome (SIRS) in cats with panleukopenia. ANIMALS Client-owned cats with FPV infection diagnosed by a positive fecal ELISA test, positive PCR on feces or blood or both. METHODS Retrospective cohort study. The electronic medical database was searched for cats with FPV infection presented between January 2010 and January 2018. Cats were divided into survivors and nonsurvivors according to their survival status 28 days after hospital admission. The prognostic importance of each variable was investigated univariately and by multivariable Cox's proportional-hazards regression. Finally, receiver operator characteristic (ROC) curve analysis was used to identify the best cutoff value for discriminating survivors from nonsurvivors for the statistically significant prognostic predictors identified by multivariable analysis. RESULTS Seventy cats were enrolled in the study. Multivariable analysis determined that only serum tT4 concentration at hospital admission was significantly (P = .01) associated with survival. A cutoff value of 0.82 μg/dL was identified by ROC curve analysis for serum tT4 concentration in discriminating survivors from nonsurvivors. Sensitivity at this cutoff was 73.9% and specificity was 82.9% (area under the curve, 0.783; 95% confidence interval, 0.668-0.873; P < .0001). CONCLUSION AND CLINICAL RELEVANCE Serum tT4 concentration at hospital admission has prognostic value in cats with FPV infection.

中文翻译：

---

系统性炎症反应综合征和急性期蛋白，胆固醇和总甲状腺素水平在全白细胞减少症猫中的预后价值。

背景技术猫细小病毒（FPV）是猫中常见的潜在致死性传染物。目的评估全白细胞减少症猫的年龄，中性状态，血清淀粉样蛋白A（SAA），触觉珠蛋白，胆固醇和总甲状腺素（tT4）的预后价值，以及是否存在全身性炎症反应综合征（SIRS）。动物粪便ELISA检测呈阳性，粪便或血液或两者同时呈阳性PCR诊断为FPV感染的客户拥有的猫。方法回顾性队列研究。在电子医学数据库中搜索了2010年1月至2018年1月之间出现FPV感染的猫。根据住院后28天的存活状况，将猫分为存活者和非存活者。对每个变量的预后重要性进行了单变量研究，并通过多变量Cox的比例风险回归进行了研究。最后，使用接收者操作员特征（ROC）曲线分析来确定最佳阈值，以通过多变量分析确定具有统计学意义的预后预测指标，从而将幸存者与非幸存者区分开。结果该研究招募了70只猫。多变量分析确定，入院时仅血清tT4浓度与生存率显着相关（P = .01）。通过ROC曲线分析，在区分幸存者和非幸存者中，血清tT4浓度的临界值为0.82μg/ dL。截止时的灵敏度为73.9％，特异性为82.9％（曲线下面积0.783； 95％置信区间0.668-0.873； P <。0001）。结论和临床意义入院时血清tT4浓度对FPV感染的猫有预后价值。