Background. Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of taxane treatment and cannot currently be prevented or adequately treated. Physical therapy is often used for neural rehabilitation following injury but has not been evaluated in this patient population. Methods. Single-blind, randomized controlled exploratory study compared standard care to a physical therapy home program (4 visits) throughout adjuvant taxane chemotherapy for stage I-III patients with breast cancer (n = 48). Patient questionnaires and quantitative sensory testing evaluated the treatment effect throughout chemotherapy to 6 months post treatment. Nonrandomized subgroup analysis observed effect of general exercise on sensory preservation comparing those reporting moderate exercise throughout chemotherapy to those that did not exercise regularly. Clinical Trial Registration. clinicaltrials.gov (NCT02239601). Results. The treatment group showed strong trends toward less pain (odds ratio [OR] 0.41, 95% confidence interval [CI] 0.17-1.01; P = .053) and pain decreased over time (OR 0.85, 95% CI 0.76-0.94; P = .002). Pain pressure thresholds (P = .034) and grip dynamometry (P < .001) were improved in the treatment group. For the nonrandomized subgroup analysis, participants reporting general exercise had preservation of vibration (Left P = .001, Right P = .001) and normal heat pain thresholds (Left P = .021, Right P = .039) compared with more sedentary participants. Conclusion. Physical therapy home program may improve CIPN pain in the upper extremity for patients with breast cancer, and general exercise throughout chemotherapy treatment was observed to have correlated to preservation of sensory function. Further research is required to confirm the impact of a physical therapy home program on CIPN symptoms.

中文翻译：

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物理疗法治疗化疗引起的周围神经病变的探索性随机试验

背景。化疗引起的周围神经病变 (CIPN) 是紫杉烷治疗的常见副作用，目前无法预防或充分治疗。物理治疗通常用于受伤后的神经康复，但尚未在该患者群体中进行评估。方法。单盲、随机对照探索性研究在 I-III 期乳腺癌患者（n = 48）的紫杉烷辅助化疗期间将标准护理与物理治疗家庭计划（4 次就诊）进行了比较。患者问卷和定量感官测试评估了整个化疗至治疗后 6 个月的治疗效果。非随机亚组分析观察了一般运动对感觉保存的影响，将化疗期间报告适度运动的患者与不经常运动的患者进行比较。临床试验注册。Clinicaltrials.gov (NCT02239601)。结果。治疗组显示出减轻疼痛的强烈趋势（比值比 [OR] 0.41，95% 置信区间 [CI] 0.17-1.01；P = .053）并且疼痛随着时间的推移而减少（OR 0.85，95% CI 0.76-0.94；P = .002）。治疗组的疼痛压力阈值 (P = .034) 和握力测量法 (P < .001) 得到改善。对于非随机亚组分析，与更多久坐不动的参与者相比，报告一般运动的参与者保持振动（左 P = .001，右 P = .001）和正常热痛阈值（左 P = .021，右 P = .039） . 结论。物理治疗家庭计划可能会改善乳腺癌患者上肢的 CIPN 疼痛，观察到整个化疗期间的一般运动与感觉功能的保持有关。需要进一步的研究来确认物理治疗家庭计划对 CIPN 症状的影响。