This cross‐sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency. Concentrations of waste anesthetic gases were measured in the operating rooms to assess anesthetic pollution. The exposed group comprised individuals occupationally exposed to inhalational anesthetics, while the control group comprised individuals without anesthetic exposure. We quantified DNA damage; genetic instability (micronucleus‐MN); protein, lipid, and DNA oxidation; antioxidant activities; and proinflammatory cytokine levels. Trace concentrations of anesthetics (isoflurane: 5.3 ± 2.5 ppm, sevoflurane: 9.7 ± 5.9 ppm, and nitrous oxide: 180 ± 150 ppm) were above international recommended thresholds. Basal DNA damage and IL‐17A were significantly higher in the exposed group [27 ± 20 a.u. and 20.7(19.1;31.8) pg/mL, respectively] compared to the control group [17 ± 11 a.u. and 19.0(18.9;19.5) pg/mL, respectively], and MN frequency was slightly increased in the exposed physicians (2.3‐fold). No significant difference was observed regarding oxidative stress biomarkers. The findings highlight the genetic and inflammatory risks in young physicians exposed to inhalational agents in operating rooms lacking adequate scavenging systems. This potential health hazard can accompany these subjects throughout their professional lives and reinforces the need to reduce ambient air pollution and consequently, occupational exposure.

中文翻译：

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高浓度的麻醉气体在暴露了三年的医生中引起了遗传损伤和炎症：一项横断面研究。

这项横断面研究分析了在医疗居住期结束后接触吸入麻醉剂的年轻医生中职业性麻醉气体对遗传物质，氧化应激和炎症状态的影响。在手术室中测量麻醉气体的浓度，以评估麻醉剂的污染。暴露组包括职业性接触吸入麻醉剂的个体，而对照组则包含无麻醉剂暴露的个体。我们量化了DNA损伤；遗传不稳定（微核-MN）；蛋白质，脂质和DNA氧化；抗氧化活性；和促炎细胞因子水平。痕量麻醉剂浓度（异氟醚：5.3±2.5 ppm，七氟醚：9.7±5.9 ppm和一氧化二氮：180±150 ppm）高于国际建议的阈值。暴露组的基础DNA损伤和IL-17A显着高于对照组[分别为27±20 au和20.7（19.1; 31.8）pg / mL]和对照组[17±11 au和19.0（18.9; 19.5）pg / mL] / mL]，而暴露的医师的MN频率略有增加（2.3倍）。关于氧化应激生物标志物未观察到显着差异。这些发现强调了缺乏足够清除系统的年轻医生在手术室中接触吸入剂的遗传和炎症风险。这些潜在的健康危害可能伴随这些受试者的整个职业生涯，并增强了减少环境空气污染并因此减少职业暴露的需求。与对照组相比[分别为17±11 au和19.0（18.9; 19.5）pg / mL]，暴露的医师的MN频率略有增加（2.3倍）。关于氧化应激生物标志物未观察到显着差异。这些发现强调了缺乏足够清除系统的年轻医生在手术室中接触吸入剂的遗传和炎症风险。这些潜在的健康危害会伴随这些受试者的整个职业生涯，并增强了减少环境空气污染并因此减少职业暴露的需求。与对照组相比[分别为17±11 au和19.0（18.9; 19.5）pg / mL]，暴露的医师的MN频率略有增加（2.3倍）。关于氧化应激生物标志物未观察到显着差异。这些发现强调了缺乏足够清除系统的年轻医生在手术室中接触吸入剂的遗传和炎症风险。这些潜在的健康危害会伴随这些受试者的整个职业生涯，并增强了减少环境空气污染并因此减少职业暴露的需求。这些发现强调了缺乏足够清除系统的年轻医生在手术室中接触吸入剂的遗传和炎症风险。这些潜在的健康危害可能伴随这些受试者的整个职业生涯，并增强了减少环境空气污染并因此减少职业暴露的需求。这些发现强调了缺乏足够清除系统的年轻医生在手术室中接触吸入剂的遗传和炎症风险。这些潜在的健康危害会伴随这些受试者的整个职业生涯，并增强了减少环境空气污染并因此减少职业暴露的需求。