Background: Icariin (ICA), one of the main effective components isolated from the traditional Chinese herb Epimedium brevicornu Maxim., has been reported to possess extensive pharmacological actions, including enhanced sexual function, immune regulation, anti-inflammation, and antiosteoporosis.

Methods: Our study was designed to investigate the effect of ICA on cell proliferation and differentiation and the molecular mechanism of OPG/RANKL mediated by the Estrogen Receptor (ER) in hFOB1.19 human osteoblast cells.

中文翻译：

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Icariin通过雌激素受体介导的OPG / RANKL刺激hFOB 1.19成骨细胞增殖和分化。

背景：鹰嘴豆素（ICAR）是从传统中草药淫羊Epi（Epimedium brevicornu Maxim）中分离出的主要有效成分之一，据报道具有广泛的药理作用，包括增强的性功能，免疫调节，抗炎和抗骨质疏松症。

方法：本研究旨在研究ICA对hFOB1.19人成骨细胞中细胞增殖和分化的影响以及雌激素受体（ER）介导的OPG / RANKL的分子机制。