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Protective Effect of the Intracellular Content from Potential Probiotic Bacteria against Oxidative Damage Induced by Acrylamide in Human Erythrocytes.
Probiotics and Antimicrobial Proteins ( IF 4.9 ) Pub Date : 2020-01-22 , DOI: 10.1007/s12602-020-09636-9
P F Cuevas-González 1 , J E Aguilar-Toalá 1, 2 , H S García 3 , A F González-Córdova 1 , B Vallejo-Cordoba 1 , A Hernández-Mendoza 1
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The aim of this study was to assess the protective effect of the intracellular content obtained from potential probiotic bacteria against acrylamide-induced oxidative damage in human erythrocytes. First, the antioxidant properties of 12 potential probiotic strains was evaluated. Two commercial probiotic bacteria were included as reference strains, namely, Lactobacillus casei Shirota and Lactobacillus paracasei 431. Data showed that the intracellular content from four strains, i.e., Lactobacillus fermentum J10, Lactobacillus pentosus J24 and J26, and Lactobacillus pentosus J27, showed higher (P < 0.05) antioxidant capacity in most methods used. Thereafter, the intracellular content of such pre-selected strains was able to prevent the disturbance of the antioxidant system of human erythrocytes exposed to acrylamide, thereby reducing cell disruption and eryptosis development (P < 0.05). Additionally, the degree of oxidative stress in erythrocytes exposed to acrylamide was significantly (P < 0.05) reduced to levels similar to the basal conditions when the intracellular content of Lact. fermentum J10, Lact. pentosus J27, and Lact. paracasei 431 were employed. Hence, our findings suggest that the intracellular contents of specific Lactobacillus strains represent a potential source of metabolites with antioxidant properties that may help reduce the oxidative stress induced by acrylamide in human erythrocytes.

中文翻译:

潜在益生菌细胞内内容物对丙烯酰胺在人体红细胞中引起的氧化损伤的保护作用。

这项研究的目的是评估从潜在的益生菌中获得的细胞内内容物对丙烯酰胺诱导的人红细胞氧化损伤的保护作用。首先,评估了12种潜在益生菌菌株的抗氧化性能。包括两个商业益生菌作为参考菌株,即干酪乳杆菌Shirota和副干酪乳杆菌431。数据显示,来自发酵菌株乳杆菌J10,戊糖乳杆菌J24和J26以及戊糖乳杆菌J27四个菌株的细胞内含量较高( P <0.05)在大多数使用的方法中的抗氧化能力。此后,此类预选菌株的细胞内含量能够防止暴露于丙烯酰胺的人体红细胞的抗氧化系统受到干扰,从而减少细胞分裂和加密发展(P <0.05)。另外,暴露于丙烯酰胺的红细胞中的氧化应激程度显着(P <0.05)降低至与Lact的细胞内含量基本条件相似的水平。发酵罐J10,乳酸。戊糖J27和Lact。使用了副干酪431。因此,我们的发现表明特定乳酸菌菌株的细胞内含量代表具有抗氧化特性的代谢物的潜在来源,这可能有助于减少丙烯酰胺在人红细胞中诱导的氧化应激。发酵罐J10,乳酸。戊糖J27和Lact。使用了副干酪431。因此,我们的发现表明特定乳酸菌菌株的细胞内含量代表具有抗氧化特性的代谢物的潜在来源,这可能有助于减少丙烯酰胺在人红细胞中诱导的氧化应激。发酵罐J10,乳酸。戊糖J27和Lact。使用了副干酪431。因此,我们的发现表明特定乳酸菌菌株的细胞内含量代表具有抗氧化特性的代谢物的潜在来源,这可能有助于减少丙烯酰胺在人红细胞中诱导的氧化应激。
更新日期:2020-01-22
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