当前位置: X-MOL 学术Mar. Biotechnol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Non-Cytotoxic Sulfated Heterorhamnan from Gayralia brasiliensis Green Seaweed Reduces Driver Features of Melanoma Metastatic Progression.
Marine Biotechnology ( IF 3 ) Pub Date : 2020-01-22 , DOI: 10.1007/s10126-020-09944-9
D L Bellan 1 , E Mazepa 2 , S M P Biscaia 1 , J P Gonçalves 1 , C C Oliveira 1 , G R Rossi 1 , L G Ferreira 2 , M D Noseda 2 , E S Trindade 1 , M E R Duarte 2 , C R C Franco 1
Affiliation  

Melanoma is a form of skin cancer with high mortality owing to its fast progression and metastatic capacity. The treatments available nowadays are only palliative in advanced stages of the disease. Thus, alternative therapies for cancer treatment are in demand, and molecules from natural sources, such as polysaccharides, could represent new possible therapeutic approaches. Polysaccharides of freshwater and marine algae with biological activities, such as antitumor properties, are greatly reported in the scientific literature. In the present study, a sulfated heterorhamnan obtained from the green seaweed Gayralia brasiliensis (Gb1 fraction) was chemically characterized and its biological activities in the B16-F10 murine melanoma cell line were evaluated. The Gb1 polysaccharidic fraction tested concentrations presented low or absence of cytotoxicity to B16-F10 cells and neither cell proliferation nor cell cycle were altered. Interestingly, Gb1 treatment decreased B16-F10 cells migration and invasion capabilities and CD44 labeling, showing to be a promising compound for further in vitro and in vivo antitumor studies.

中文翻译:

来自巴西盖拉利亚绿色海藻的无细胞毒性的硫酸异杂聚糖减少黑素瘤转移进程的驱动程序特征。

黑色素瘤是一种皮肤癌,由于其快速发展和转移能力而具有很高的死亡率。当今可用的治疗仅在疾病的晚期缓解。因此,需要用于癌症治疗的替代疗法,并且天然来源的分子,例如多糖,可能代表了新的可能的治疗方法。科学文献中大量报道了具有生物活性,例如抗肿瘤性质的淡水和海藻多糖。在本研究中,从绿色海藻巴西草(Gayralia brasiliensis)获得了硫酸化的异鼠李聚糖(Gb1级分)进行了化学表征,并评估了其在B16-F10小鼠黑色素瘤细胞系中的生物学活性。Gb1多糖级分的测试浓度对B16-F10细胞呈现低毒性或无细胞毒性,并且细胞增殖和细胞周期均未改变。有趣的是,Gb1处理降低了B16-F10细胞的迁移和侵袭能力以及CD44标记,显示它是用于进一步体外和体内抗肿瘤研究的有希望的化合物。
更新日期:2020-01-22
down
wechat
bug