The consumption of fructose during pregnancy can cause hyperglycaemia and may stimulate production of reactive oxygen species; however, there are only a few studies reporting whether fructose consumption during pregnancy causes DNA damage. Therefore, the aim of this study was to evaluate the effects of fructose consumption on genetic and biochemical parameters in Swiss mice treated during pregnancy and lactation. For this, 15 couples of 60-day-old Swiss mice were divided into three groups of five couples: negative control (water) and two fructose groups (fructose dose of 10%/l and 20%/l). During this period, we evaluated food consumption, energy efficiency and body weight. Samples of blood were collected from the females before copulation, after the 15th day of conception and on the 21st day after the lactation period, for the glycaemic and lipid profiles as well as comet assay and micronucleus (MN) test. Comet assay and MN test evaluate DNA damage and clastogenicity, respectively. In the gestation and lactation period, the two fructose doses tested showed DNA damage as observed in the comet assay, which is associated with an increase in dietary intake, body weight, lipid profile and fasting glycaemia in females. Thus, it can be suggested that the high consumption of fructose during these periods is harmful for pregnancy and lactation.

中文翻译：

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怀孕和哺乳期食用果糖会导致雌性小鼠的DNA损伤和生化变化。

在怀孕期间食用果糖会引起高血糖症，并可能刺激活性氧的产生。但是，仅有少数研究报道了怀孕期间果糖的摄入是否会导致DNA损伤。因此，本研究的目的是评估果糖摄入量对妊娠和哺乳期瑞士小鼠遗传和生化指标的影响。为此，将15对60天大的瑞士小鼠分为三组，每组五对：阴性对照（水）和两个果糖组（果糖剂量分别为10％/ l和20％/ l）。在此期间，我们评估了食物消耗，能源效率和体重。在交配前，受孕第15天后和哺乳期后第21天从雌性身上采集血液样本，进行血糖和脂质分析以及彗星分析和微核（MN）测试。彗星试验和MN试验分别评估DNA损伤和致胶性。在妊娠期和哺乳期，两次测试的果糖剂量均显示出彗星试验中观察到的DNA损伤，这与女性饮食摄入，体重，脂质分布和空腹血糖增加有关。因此，可以认为在这些时期中高果糖的摄入对怀孕和哺乳有害。女性的脂质分布和空腹血糖。因此，可以认为在这些时期中高果糖的摄入对怀孕和哺乳有害。女性的脂质分布和空腹血糖。因此，可以认为在这些时期中高果糖的摄入对怀孕和哺乳有害。