Background: Pathogens use multiple mechanisms to disrupt cell functioning in their host and allow pathogenesis. These mechanisms involve communication between the pathogen and the host cell through protein-protein interactions.

Methods: Protein-protein interactions chains referred to as signal transduction pathways are the processes by which a chemical or physical signal transmits through a cell as series of molecular events so the pathogen needs to intercept these molecular pathways at few positions to induce pathogenesis such as pathogen viability, infection or hypersensitivity.

Results: The pathogen nodes of interception are not necessarily the most immunogenic; so that novel immunogenicity-improvement strategies need to be developed thought a chemical conjugation of the pathogen-carrier nodes to develop an efficient immune response in order to block pathogenesis. On the other hand, if pathogen-carriers are immunogens; toleration ought to be induced by this conjugation avoiding hypersensitivity. Thus, this paper addresses the biological plausibility of plant-phenolics as pathogen-carrier immunogenicity modulator haptens.

Conclusion: The plant-phenolic compounds have in their structure functional groups such as hydroxyl, carbonyl, carboxyl, ester, or ether, capable of reacting with the amino or carbonyl groups of the amino acids of a pathogen-carrier to form conjugates. Besides, the varied carbon structures these phenolic compounds have; it is possible to alter the pathogen-carrier related factors that determine the immunogenicity: 1) Structural complexity, 2) Molecular size, 3) Structural heterogeneity, 4) Accessibility to antigenic determinants or epitopes, 5) Optical configuration, 6) Physical state, or 7) Molecular rigidity.

背景：病原体利用多种机制破坏宿主细胞的功能并允许发病。这些机制涉及病原体与宿主细胞之间通过蛋白质-蛋白质相互作用的通讯。

方法：蛋白质-蛋白质相互作用链称为信号转导途径，是化学或物理信号作为一系列分子事件通过细胞传递的过程，因此病原体需要在几个位置截断这些分子途径以诱导发病机理，例如病原体生存力，感染或超敏反应。

结果：截获的病原体不一定是最具免疫原性的。因此，需要发展新的免疫原性改善策略，考虑到病原体-携带者节点的化学结合，以开发有效的免疫应答，从而阻断发病机理。另一方面，如果病原体携带者是免疫原；这种结合应引起耐受，避免超敏反应。因此，本文探讨了植物酚类作为病原体-载体免疫原性调节剂半抗原的生物学可行性。

结论：植物酚类化合物在结构上具有官能团，例如羟基，羰基，羧基，酯或醚，能够与病原体载体的氨基酸的氨基或羰基反应形成结合物。此外，这些酚类化合物具有变化的碳结构。可以改变确定免疫原性的病原体-载体相关因素：1）结构复杂性，2）分子大小，3）结构异质性，4）接近抗原决定簇或表位，5）光学构型，6）物理状态，或7）分子刚性。