Known as PACE­B, it is one cohort of the Prostate Advances in Comparative Evidence study. The randomized, open­label, phase 3, noninferiority trial was conducted at 37 centers in the United Kingdom, Ireland, and Canada. “We believe this is the first study to show that 5 frac­ tions of radiotherapy can be deliv­ ered without any detriment to acute toxicity, potentially changing clinical practice guidelines for prescribing radiotherapy,” says study author Nicholas John van As, MD, medical director at The Royal Marsden Hospital and The Institute of Cancer Research in London, United Kingdom.

中文翻译：

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增加辐射强度对治疗前列腺癌是安全的

它被称为 PACEB，是比较证据研究中前列腺进展的一个队列。这项随机、开放标签、3 期、非劣效性试验在英国、爱尔兰和加拿大的 37 个中心进行。“我们相信这是第一项表明可以进行 5 次放疗而不会对急性毒性造成任何损害的研究，这可能会改变开具放疗处方的临床实践指南，”该研究的作者、医学博士、医学博士 Nicholas John van As 说。英国伦敦皇家马斯登医院和癌症研究所。