Rhodococcus equi, a member of the Rhodococcus genus, is a gram-positive pathogenic bacterium. Rhodococcus possesses an open pan-genome that constitutes the basis of its high genomic diversity and allows for adaptation to specific niche conditions and the changing host environments. Our analysis further showed that the core genome of R. equi contributes to the pathogenicity and niche adaptation of R. equi. Comparative genomic analysis revealed that the genomes of R. equi shared identical collinearity relationship, and heterogeneity was mainly acquired by means of genomic islands and prophages. Moreover, genomic islands in R. equi were always involved in virulence, resistance, or niche adaptation and possibly working with prophages to cause the majority of genome expansion. These findings provide an insight into the genomic diversity, evolution, and structural variation of R. equi and a valuable resource for functional genomic studies.

中文翻译：

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马红球菌的比较基因组分析：对基因组多样性和基因组进化的见解。

马红球菌属的成员，是革兰氏阳性致病菌。红球菌拥有开放的全基因组，构成了其高基因组多样性的基础，并可以适应特定的生态位条件和不断变化的宿主环境。我们的分析进一步表明，马齿。的核心基因组有助于马齿the的致病性和生态位适应。比较基因组分析揭示的基因组马红球菌共有的相同的共线性关系，和异质性主要是由基因组岛和原噬菌体的手段获得。在此外，基因组岛马红球菌它们总是参与毒力，抗性或生态位适应，并可能与噬菌体一起导致大部分基因组扩增。这些发现提供了深入了解基因组多样性，进化和结构变异马红球菌和功能基因组学研究的宝贵资源。