Annually, there are many bladder cancer patients undergoing radical cystectomy (RC) with urinary diversion worldwide. Until 2019, intestinal cystoplasty is still the gold standard for bladder replacement, but this therapy is always associated with severe complications. An ideal bladder substitute without using intestinal tissue remains a challenge today. In this work, an artificial mechatronics bladder (AMB) as a brand new bladder replacement approach is developed. We studied the main physiological function characteristics of a natural urinary bladder from teaching books and relevant papers. According to these characteristics, we completed an overall design of AMB and made a prototype in lab. The prototype successfully realized the functions of a natural bladder in vitro. It can expand to store urine in real time when urine is flowing into it. It can send a urination alarm when it is fully filled and can void urine automatically after receiving remote control signals. According to relevant papers and our test experience, if the prototype could be smaller and lighter and manufactured with good biocompatibility materials such as PTFE, we think it is possible for AMB to be implanted in an animal’s body, and we deduce AMB could realize the functions of a natural urinary bladder in vivo. After thorough validation from animal testing, we hope AMB can be a good clinical option for bladder removal patients in the future.

中文翻译：

---

膀胱机电一体化模型的设计及其原型的实现与评估。

每年，全世界都有许多膀胱癌患者接受根治性膀胱切除术（RC）并转移尿液。直到2019年，肠膀胱成形术仍然是膀胱置换术的金标准，但是这种疗法总是伴随着严重的并发症。如今，不使用肠组织的理想膀胱替代品仍然是一个挑战。在这项工作中，作为一种崭新的膀胱替代方法，人造机电膀胱（AMB）得以开发。我们从教科书和相关论文中研究了天然膀胱的主要生理功能特征。根据这些特征，我们完成了AMB的总体设计并在实验室中制作了原型。该原型在体外成功实现了天然膀胱的功能。当尿液流入时，它可以扩展以实时存储尿液。充满后，它会发出排尿警报，并在接收到遥控信号后自动排尿。根据相关论文和我们的测试经验，如果原型可以更小，更轻并且使用具有良好生物相容性的材料（例如PTFE）制造，我们认为AMB可以植入动物体内，并且我们推断AMB可以实现功能在体内天然膀胱。经过动物实验的全面验证，我们希望AMB将来可以成为膀胱切除患者的良好临床选择。如果原型能够更小，更轻并且使用具有良好生物相容性的材料（例如PTFE）制造，我们认为AMB可以植入动物体内，并且我们推断AMB可以在体内实现天然膀胱的功能。经过动物实验的全面验证，我们希望AMB将来可以成为膀胱切除患者的良好临床选择。如果原型能够更小，更轻并且使用具有良好生物相容性的材料（例如PTFE）制造，我们认为AMB可以植入动物体内，并且我们推断AMB可以在体内实现天然膀胱的功能。经过动物实验的全面验证，我们希望AMB将来可以成为膀胱切除患者的良好临床选择。