Diseases are natural components of the environment, and many have economic implications for aquaculture and fisheries. Aquaculture is a fast-growing industry with the aim to meet the high protein demand of the ever-increasing global population; however, the emergence of diseases is a major setback to the industry. Probiotics emerged as a better solution to curb the disease problem in aquaculture among many alternatives. Probiotic Bacillus has been proven to better combat a wide range of fish pathogens relative to other probiotics in aquaculture; therefore, understanding the various mechanisms used by Bacillus in combating diseases will help improve their mode of action hence yielding better results in their combat against pathogens in the aquaculture industry. Thus, an overview of the mechanisms (production of bacteriocins, suppression of virulence gene expression, competition for adhesion sites, production of lytic enzymes, production of antibiotics, immunostimulation, competition for nutrients and energy, and production of organic acids) used by Bacillus probiotics in mitigating fish pathogens ranging from Aeromonas, Vibrio, Streptococcus, Yersinia, Pseudomonas, Clostridium, Acinetobacter, Edwardsiella, Flavobacterium, white spot syndrome virus, and infectious hypodermal and hematopoietic necrosis virus proven to be mitigated by Bacillus have been provided.

疾病是环境的自然组成部分，许多疾病对水产养殖和渔业具有经济影响。水产养殖业是一个快速发展的产业，其目标是满足不断增长的全球人口对蛋白质的高需求；然而，疾病的出现是该行业的主要挫折。益生菌作为控制水产养殖疾病的一种更好的解决方案，出现在许多替代方案中。事实证明，与水产养殖中的其他益生菌相比，益生芽孢杆菌能更好地抵抗多种鱼类病原体。因此，了解芽孢杆菌使用的各种机制抗击疾病将有助于改善其作用方式，从而在水产养殖业中对抗病原体产生更好的结果。因此，概述了芽孢杆菌益生菌使用的机制（细菌素的产生，毒力基因表达的抑制，对粘附位点的竞争，裂解酶的产生，抗生素的产生，免疫刺激，营养物和能量的竞争以及有机酸的产生）在减轻鱼病原体中的作用，包括气单胞菌，弧菌，链球菌，耶尔森氏菌，假单胞菌，梭菌，不动杆菌，爱德华氏菌，黄杆菌，白斑综合征病毒和传染性皮下及造血组织坏死病毒被证明通过减轻芽孢杆菌已被提供。