Although alpha-synuclein has been reported to participate in neurodegenerative diseases, the actual normal biological function of alpha-synuclein remains unclear. I investigated the correlation of alpha-synuclein expression with nocturnal and diurnal activity for various species. Hematoxylin and eosin staining, periodic acid-Schiff’s reaction (PAS) and immunohistochemistry of alpha-synuclein expression were performed for the retinas of diurnal, nocturnal, nocturnal with diurnal activity species. I found different intensity of alpha-synuclein expression in the retinal layers. I found alpha-synuclein expression in the outer segment of the photoreceptor layer in the diurnal studied species and absence of alpha-synuclein expression in the compartments of photoreceptor layer in the retina of nocturnal species. I found localization of alpha-synuclein in the inner and outer segments of photoreceptors of the retina of nocturnal with diurnal activity species. The retinas of diurnal animals exhibited glycogen in the paraboloid structure in the inner segment of the photoreceptor layer. The retinas of nocturnal and nocturnal with diurnal activity species were devoid of glycogen in the photoreceptor layer. I conclude that the function of alpha-synuclein is more related to diurnal than to nocturnal species.

尽管已经报道了α-突触核蛋白参与神经退行性疾病，但是α-突触核蛋白的实际正常生物学功能仍不清楚。我研究了α-突触核蛋白表达与各种物种的夜间活动和昼夜活动之间的关系。对昼夜活动，夜间活动和夜间活动的视网膜进行苏木精和曙红染色，高碘酸雪夫反应（PAS）和α-突触核蛋白表达的免疫组织化学。我在视网膜层中发现了不同强度的α-突触核蛋白表达。我发现昼夜研究物种的感光层外段中有α-突触核蛋白表达，而夜间物种的视网膜中感光层的隔室中没有α-突触核蛋白表达。我发现夜间活动性视网膜夜间视网膜感光器的内部和外部部分中存在α-突触核蛋白。昼夜动物的视网膜在感光层内部部分的抛物面结构中显示糖原。夜活动性和夜间活动性视网膜的视网膜在感光层中没有糖原。我得出结论，α-突触核蛋白的功能与昼夜活动有关，而不与夜间活动有关。